Preceding the study of the effect of digitalis upon coagulation of the blood, the reliability of the Lee and White method was determined in 173 normal adults. The effect of digitalis was then studied in cardiac patients before and after coinpenation and with normal controls in eaegroup: digitalis in clinical doses; addition of heparin to the blood; the heparin tolerance curve; the substitution ...

Dyspnea may be a symptom of pulmonary or cardiac disease or both. In the dyspnea of cardiac origin, digitalis is generaly considered specifcally indicated. However, in some circumstances digitalis may provide little or no relief of cardiac dyspnea. In early failure when there are no physical signs of congestion, relief of dyspnea is unimpressive and equivocal. In frank failure, digitalis helps ...

The most commonly used preparation of digitalis is digoxin, which is obtained from the leaves of Digitalis lanata, a common flowering plant called “foxglove.” The words digitalis and digoxin in this article are used interchangeably. An exhaustive review published in 19961 cited a large number of references and had detailed data and descriptions of a large number of studies and all early trials....

Numerous electrocardiographic studies have been made in rheumatic fever, diphtheria and other acute infectious diseases ( 1, 2, 3, 4, 5), but a search of the literature yields relatively little information on the changes in the heart depicted by the electrocardiogram in lobar pneumonia. Cohn and Jamieson (6) in a report on the action of digitalis in this disease discussed the tracings obtained ...

Digitalis drugs are selective inhibitors of the plasma membrane Na+/K+-ATPase. There are many studies on molecular mechanisms of digitalis interaction with purified pig kidney enzyme, with the tacit assumption that it is a good model of human kidney enzyme. However, previous studies on crude or recombinant human kidney enzymes are limited, and have not resulted in consistent findings on their d...

Controversy exists over the rapidity of onset of the inotropic effect of various digitalis glycosides. Shortening of the systolic time intervals (STI) provides a quantitative measure of the inotropic effect of digitalis glycosides in human subjects. Total electromechanical systole corrected for heart rate (QS2I) is the most sensitive of the STI since it combines the shortening effect of digital...

I NDICATION FOR DIGITALIZATION of patients with cardiovascular disease has long been the presence of manifest heart failure or some specific arrhythmias, atrial flutter, atrial fibrillation and sometimes other atrial tachycardias. The presence of heart disease as such has not been thought to be sufficient indication to start a patient on digitalis therapy, mostly for two reasons. First, because...

The effect of intracarotid injections of ouabain (25.0 ng) or acetylstrophanthidin (1.56 tig) on feline carotid sinus baroreceptors was evaluated using an isolated perfused carotid sinus preparation. The effects of the drugs on baroreceptor activity were determined by monitoring carotid sinus nerve activity and systemic arterial blood pressure. Administration of either drug to the isolated caro...