Neuregulin/ErbB2-induced kinase signaling provides essential survival and protection clues for functional integrity of the adult heart and skeletal muscle. To define the regulatory pathways involved in neuregulin-dependent muscle cell survival, we set out to map the largely unknown transcript targets of this growth/differentiation factor in cardiocytes. Freshly isolated adult primary rat cardio...

Neuregulin-1 has a key role in mediating signaling between axons and Schwann cells during development. A limitation to studying its role in adulthood is the embryonic lethality of global Nrg1 gene deletion. We used the Cre-loxP system to generate transgenic mice in which neuregulin-1 is conditionally ablated in the majority of small-diameter and a proportion of large-diameter sensory neurons th...

At the neuromuscular synapse, innervation induces endplate-specific expression of adult-type nicotinic acetylcholine receptors by selective expression of their subunit-encoding genes (a2b«d) in endplate-associated myonuclei. These genes are specifically regulated by protein-tyrosine phosphatase (PTPase) activity. In addition, neureguliny acetylcholine-receptor-inducing activity, a nerve-derived...

OBJECTIVES Neuregulin 1 signaling plays an important role in cardiac trabecular development, and in sustaining functional integrity in adult hearts. Treatment with neuregulin 1 enhances adult cardiomyocyte differentiation, survival and/or function in vitro and in vivo. It has also been suggested that recombinant neuregulin 1β1 (NRG1β1) induces cardiomyocyte proliferation in normal and injured a...

The present study was conducted to evaluate the expression of caspase-3, caspase-9, growth differentiation factor-9 (GDF-9) and insulin factor-1 (IGF-1) genes in oocytes cultured vitro with optimum elevated doses amphiregulin (50 ng 150 ng), neuregulin-1 (25 ng) tumor necrosis factor-α during maturation based on results effects AREG or NRG-1 TNF-α concentration which caused significant effect, ...

Neuregulin 1 (NRG1) is one of Neuregulin proteins, a kind of epidermal growth factor encoded by the selective shear of NRG1 gene, which promotes proliferation, differentiation and survival of neurons, muscle and other cells. NRG 1 has an important regulating function on female reproductive endocrine. The research development of NRG1 in the field of animal reproductive endocrine is described on ...

Background. The role of recently discovered neurospecific peptides in the pathogenesis acute and progressive neurologic disorders, their neuroprotective features, possibilities to use them as markers for course prognosis certain diseases have been actively studied recent decades. However, are almost not chronic residual diseases. In our study we measured levels some other achieve understanding ...

The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia. Specifically, the T allele of NRG3 rs10748842 has been associated with illness risk, altered cognitive function, and the expression of a novel splice isoform in prefrontal cortex (PFC), but the neural system effects are unexplored. Here, we report an association bet...

Aberrant neuregulin-1 (NRG1) signals are suggested to associate with the neuropathophysiology of schizophrenia. Employing a mouse schizophrenia model established by neonatal neuregulin-1 challenge, we analysed postpubertal consequence of the NRG1 pretreatment for the electrophysiological property of nigral dopamine neurons. In vivo single unit recordings from anaesthetized NRG1-pretreated mice ...

We have examined the expression of neuregulin and its putative receptors, erbB2/neu, erbB3 and erbB4/tyro2 during retinal development, and tested several potential functions of this class of molecules in dissociated rat retinal cell cultures. At least one form of neuregulin is expressed in the retina, from the earliest stages of retinal development examined; in addition, all three of the known ...