نتایج جستجو برای: neurofilament proteins
تعداد نتایج: 557488 فیلتر نتایج به سال:
Intact neurofilaments were isolated in parallel from rat peripheral nerve and spinal cord by osmotic shock into hypotonic media containing divalent cation chelators. Isolated neurofilaments were washed and separated by multiple centrifugations in 0.1 M NaCl. Abundant intact neurofilaments were identified in the washed pellets by negative staining techniques. Their origin from neurofilaments was...
The distribution of neurofilament immunoreactivity in the substantia nigra was examined by immunohistochemistry in five patients dying with Parkinson's disease and six control patients dying without neurological disease. In controls, pigmented neurons in the substantia nigra were intensively labelled by SMI32, a monoclonal antibody to non-phosphorylated neurofilament protein. In the substantia ...
The extensive enzymic dephosphorylation of neurofilaments determined the progressive loss of their capacity to interconnect in vitro into a reticulated network, measured by the formation of highly viscous gels in purified preparations of neurofilaments [Leterrier & Eyer (1987) Biochem. J. 245, 93-101]. Conversely, a cyclic AMP-dependent activation of the gelation process was obtained by phospho...
Polymer microlenses have been manufactured by delivering droplets of a monomer mixture to a glass substrate using a nano fountain pen (NFP). Subsequent UV polymerization yielded microlenses with optical properties that were controlled by varying the deposition time of the monomer solution. Using this approach, it is possible to strategically place single microlenses at predefined positions with...
The NFP is a program of prenatal and infancy home visiting by nurses in which they have three major goals: 1) to improve the outcomes of pregnancy by helping women improve their prenatal health; 2) to improve the child’s health and development by helping parents provide more competent care of their children the first two years of life; and 3) to improve families’ economic self-sufficiency by he...
The identification of molecular motors that modulate the neuronal cytoskeleton has been elusive. Here, we show that a molecular motor protein, myosin Va, is present in high proportions in the cytoskeleton of mouse CNS and peripheral nerves. Immunoelectron microscopy, coimmunoprecipitation, and blot overlay analyses demonstrate that myosin Va in axons associates with neurofilaments, and that the...
The sera of patients with small cell carcinoma of the lung (SCCL) and an associated visual paraneoplastic syndrome (VPNS) have high titer immunoglobulins that react with retinal ganglion cells and with cloned lines of the SCCL. The immunoglobulins in the sera of two patients with SCCL and VPNS reacted with at least one common antigen shared by neural cells and cloned lines of the SCCL. The mole...
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