When modulators of neuromuscular function alter the motor neuron spike patterns that elicit muscle contractions, it is predicted that they will also retune correspondingly the connecting processes of the neuromuscular transform. Here we confirm this prediction by analyzing data from the cardiac neuromuscular system of the blue crab. We apply a method that decodes the contraction response to the...

4.5. Bisbenzyl-isoquinolinium compounds 4.5.2. Mivacurium 4.6. Reversal of non-depolarizing neuromuscular block by anticholinesterases 4.7. Other neuromuscular uses of anticholinesterases 4.8. Pharmacokinetics of non-depolarizing neuromuscular blocking drugs 4.8.1 Clearance of non-depolarizing neuromuscular blocking drugs and duration of action 5. Depolarizing neuromuscular blocking drugs 5.1. ...

Anesthetists frequently provide intraoperative muscle relaxation in addition to general anesthesia. However, visual interpretation of the effect of neuromuscular blocking drugs is not always possible. This study examined two alternative methods (electromyography/electrocardiography [EMG/ECG] and mechanical/ECG) of interpreting neuromuscular blockade and compared these methods to visual interpre...

This review outlines the basic pharmacodynamic and pharmacokinetic properties of sugammadex for the cardiac anesthesiologist. It describes the different clinical scenarios when sugammadex can be used during cardiac surgery and gives clinical recommendations. Sugammadex is a unique reversal drug that binds a chemical complex with rocuronium and vecuronium, by which the neuromuscular blockade is ...

The neuromuscular junctions are the specialized synapses whereby spinal motor neurons control the contraction of skeletal muscles. The formation of the neuromuscular junctions is controlled by a complex interplay of multiple mechanisms coordinately activated in motor nerve terminals and in their target myotubes. However, the transcriptional regulators that control in motor neurons the genetic p...

OBJECTIVE In this study, we intended to evaluate whether swallow treatment with neuromuscular electrical stimulation is superior to that without neuromuscular electrical stimulation, and whether neuromuscular electrical stimulation alone is superior to swallow therapy. METHODS We searched the PubMed and Scopus databases from their earliest record to 31 December 2014 for randomized and quasi-r...