Stem cell-based therapy seems to be a promising strategy to treat neurodegenerative diseases, in particular those that are fatal and difficult to treat. However, the sources of stem cells are required to comply with the requirement of availability and expanding in culture, to overcome ethical objections and concerns of graft rejection. Mesenchymal stem cells (MSCs) are population of adult stem ...

481 Fom the point of view of oligodendrocyte and demyelinated axon interaction, glial scars of reactive astrocytes obstruct to myelinating oligodendrocytes the access to naked axons. On the other hand, astrocytes also produce neurotrophic factors that promote remyelination. An alternative strategy that CNS cells have to avoid axonal damage, when remyelination is not efficient, consists in that ...

Aditi Falnikar,1 Shubha Tole,2 Mei Liu,3 Judy S. Liu,4 and Peter W. Baas1,* 1Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA 2Department of Biological Sciences, Tata Institute of Fundamental Research, Colaba, Mumbai 400 005, India 3Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China 4C...

1. Department of Ophthalmology, Duke University School of Medicine, Durham. NC.USA 4 2. Department of Mechanical Engineering and Materials Science, Pratt School of 5 Engineering, Duke University. Durham. NC.USA 6 3. Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, United 7 Kingdom 8 4. Howard Hughes Medical Institute, Chevy Chase, MD 20815; Department of 9 Biochemistry...

Jin-chong Xu, Valina L Dawson and Ted M Dawson* Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA and Depart...

spinal cord injury (sci) is a destructive event that often lead to permanent neurologic deficit. current clinical treatments are aimed at preventing secondary damage, promoting regeneration, and replacing destroyed spinal cord tissue, although effective treatments for sci remain limited. cell therapies for treating sci are promising therapy for replacing dead cells, neuroprotection and axon reg...

1 Paracelsus Medical University, Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria 2 Paracelsus Medical University, Institute of Molecular Regenerative Medicine, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Strubergasse 22, 5020 Salzburg, Austria 3 University Cli...

This study investigates the efficacy of local and intravenous mesenchymal stem cell (MSC) administration to augment neuroregeneration in both a sciatic nerve cut-and-repair and rat hindlimb transplant model. Bone marrow-derived MSCs were harvested and purified from Brown-Norway (BN) rats. Sciatic nerve transections and repairs were performed in three groups of Lewis (LEW) rats: negative control...