Anti-neutrophil cytoplasmic auto antibodies are directed against antigens in the neutrophil granules. Their detection by the indirect immunofluorescence clearly divides them into two distinct types, namely c-ANCA (Classical antineutrophil cytoplasmic antibody) and the p-ANCA (Perinuclear antineutrophil cytoplasmic antibody). These antibodies have been found to be useful as non-invasive markers ...

The observation data of 22 children with systemic vasculitis (SV) and morphologically verified nephritis is presented. Emphasis was put on extrarenal manifestations SV in childhood, analysis clinical, laboratory, immunological, morphological changes factors influencing the course prognosis. It has been established that often manifests general non-specific constitutional symptoms, involvement EN...

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides are characterized by destruction of small vessels, granulomatous inflammation of the respiratory tract and necrotizing glomerulonephritis. This review describes the clinical diagnosis and therapy as well as the pathophysiology of ANCA-associated vasculitides with a specific focus on the interplay of ANCAs with activated neutrop...

The detection of a nuclear anti-neutrophil antibody in patients with primary sclerosing cholangitis (PSC), using an immunoperoxidase technique, was recently reported by us. Subsequently, detection of a cytoplasmic anti-neutrophil antibody was reported by others, using a two stage procedure of enzyme linked immunosorbent assay followed by an immunofluorescent method. Detection of cytoplasmic ant...

background : many studies have investigated the effects of psychological factors on disease activity in patients with ulcerative colitis (uc). however, the number of studies that have assessed the correlation between immunologic markers of uc and psychological distress are few. therefore, we designed a study to determine the association between two immuno-biological markers, peripheral/central ...