Platelet-activating factor (PAF) acting via its receptor (PAFR) is implicated in the pathogenesis of persistent pulmonary hypertension of the newborn (PPHN). Effects of long-term oxygen therapy on newborn lung are not well understood; therefore, we studied the effect of oxygen tension on ovine newborn pulmonary artery smooth muscle cells (NBPASMC). Our global hypothesis is that PPHN results fro...

I . Groups of lambs were killed immediately after birth; others were reared on a diet of COW’S milk and were killed at I O , Z O and 30 d after birth. The concentrations of IS : zw6 (linoleic acid) were determined in cow’s milk and the concentrations of 18:zw6, z0:4w6 (arachidonic acid) and zo: 3w9 (A68, l1 eicosatrienoic acid) were determined in the whole carcasses of the lambs. 2. The carcass...

Analysis of factors which may influence oxygen metabolism of the heart has received much attention since the early part of this century (1). Quantitative measurements of coronary blood flow and myocardial oxygen consumption (MVO,) have been accumulated from both human and animal studies (2, 3). These studies were uniformily concerned with adults, however, and virtually no information is availab...

The influences of reflexly induced changes of sympathetic outflow to the heart on left ventricle contractility, heart rate, and systemic vascular resistance were studied in 26 technically successful experiments with newborn lambs ranging in age from 1 to 11 days. Reduction of brachiocephalic artery perfusion pressure was associated with a large increase of heart rate and of systemic vascular re...

There is an abundance of evidence which suggests that hypercapnia impairs the performance of isolated heart-lung preparations, and that this is primarily consequent to diminished contractility of the myocardium.'7 Patterson' showed that the cardiac depressant effect of CO2 could be prevented largely by the addition of epinephrine. In intact adult dogs acidosis produced by CO2 retention causes s...

In this study were used 40 newborn singleton Akkaraman and Merino lambs with 4 trial groups consisting of selected 10 homogeneous according to race gender. Trial was carried out 100 days, covering 5 feeding periods 21-day from the birth lambs. The fed lamb starter feed for first two months, then grower ad-libitum 250 g/day/head dry alfalfa hay. At end study; it determined that lowest total anti...