Autoimmune haemolytic anaemia (AIHA) is a rare (prevalence 0.2 -1.0 per 100,000 population) but a potentially fatal condition. Diagnosis of AIHA is based mainly on Direct Agglutination Test (DAT/Coomb's test). AIHA is classified into warm (optimal autoantibody reactivity at 37°C) and cold (optimal autoantibody reactivity at 4°C) types. Based on the presence or absence of an underlying cause, it...

CD47 deficiency results in lethal autoimmune haemolytic anaemia (AIHA) and mild spontaneous thrombocytopenia in non-obese diabetic mice. It is unknown whether CD47 has an impact on AIHA of the warm type or autoimmune thrombocytopenia (ITP) in humans. Healthy blood donors (n= 11), patients with AIHA (n= 13), patients with ITP (n= 18) and one patient with Rh(null) phenotype were investigated. CD4...

OBJECTIVE To present and discuss the treatment of autoimmune hemolytic anemia (AIHA). METHODS The medical records of all patients (n=19) diagnosed in a tertiary hematology center between 1999 and 2010 were retrospectively reviewed. RESULTS Median age at diagnosis of AIHA was 5 years (range: 4 months-17 years). In all, 13 patients had primary (idiopathic) AIHA, whereas 2 had primary Evans Sy...

Autoimmune haemolytic anaemia (AIHA) is known to be associated with Hodgkin's disease (HD) but is uncommon. It usually presents at the time of initial diagnosis of HD or during the course of the disease but AIHA preceding the diagnosis of HD is very rare. We describe here 2 cases of AIHA who presented one year before the diagnosis of HD. There was no evidence of a coexisting disease at initial ...

BACKGROUND The occurrence of autoimmune hemolytic anemia (AIHA) in patients with non-Hodgkin's lymphoma (NHL) is well known. However, there is lack of information in the literature in terms of the significance and impact of such phenomenon on the clinical course of these patients. PATIENTS AND METHODS We analyzed the clinical and laboratory features, course and response of 16 patients with no...

Coombs' negative autoimmune hemolytic anemia (AIHA) is a rare disease which shares similar clinical and hematological features with Coombs' positive AIHA, but its exact frequency remains unknown. There have been few reports of idiopathic thrombocytopenic purpura (ITP) and Coombs' negative AIHA associated with other lymphoproliferative disorders (LPDs). Since there is a well known association be...

.. Objectives: Autoimmune hemolytic anemia (AIHA)an immunological disease resulting from red cell hemolysis caused by circulating autoantibodies against antigens on red cell membrane. Positive direct antiglobulin test (DAT) always exist in association with AIHA and form basis for its serologic diagnosis. The objective of our study was to determine clinical presentation and etiological pattern i...

Az autoimmun hemolitikus anémia (AIHA) ritka hematológiai kórkép, amelynek hátterében autoantitest okozta vörösvérsejt-destrukció áll. esetek körülbelül 50%-a idiopátiás vagy primer AIHA, míg a szekunder infekció, szisztémás betegség, szolid tumorok, limfoproliferatív betegségek, gyógyszermellékhatás A SARS-CoV-2 vírus Covid-19-pandémia jelentkezése óta megnőtt azon AIHA-s betegek száma, ahol i...

We thank Maquet et al 1 for their interest on our article entitled ‘Increased risk of systemic lupus erythematosus (SLE) in patients with autoimmune haemolytic anaemia (AIHA): a nationwide population-based cohort study’2 and the by Zhu 3 ‘Risk idiopathic thrombocytopenic purpura (ITP): study’. The articles us2 studied Taiwanese National Health Insurance Database reported that AIHA ITP have high...