RATIONALE Methylmalonic acidemia (MMA) is a common organic acidemia, mainly due to methylmalonyl-CoA mutase (MCM) or its coenzyme cobalamin (VitB12) metabolic disorders. Cobalamin C (CblC) type is the most frequent inborn error of cobalamin metabolism; it can develop symptoms in childhood and often combine multisystem damage, which leads to methylmalonic acid, propionic acid, methyl citrate, an...

Neonatal exposure to hyperoxia alters lung development in mice. We tested if retinoic acid (RA) treatment is capable to affect lung development after hyperoxic injury and to maintain structural integrity of lung. The gene of vascular endothelial growth factor A (VEGF-A) is one of the RA-responsive genes. Newborn BALB/c mice were exposed to room air, 40% or 80% hyperoxia for 7 days. One half of ...

The primary goal of this study was to investigate the formability Nimonic 90 sheet which performs well at high temperatures and pressures, making it ideal for applications in aerospace, processing, manufacturing industries. In present study, finite element analysis (FEA) optimization process parameters hydroforming were investigated. material’s mechanical properties obtained by uniaxial tensile...

Powder mixed electrical discharge machining (PM-EDM) is a technological advancement in (EDM) processes where fine powder added to dielectric improve the rate and surface quality. In this paper, of Nimonic-90 was carried out using fabricated PM-EDM, setup by adding silicon kerosene oil. The influence four input process parameters viz. concentration (PC), current (IP), spark on duration (SON), of...

Nickel based super alloys are fast gaining relevance and importance in the aerospace and steam power industries, as they have high strength to weight ratio, and exhibit superior mechanical properties. In addition, they possess high resistance at high temperatures; maintaining their resistance to corrosion, thermal shock, creep and erosion at elevated temperatures. Nickel based alloys contain a ...

Introduction: Hybrid technology has been successfully incorporated into the industry of passenger and commercial vehicles. Driven by success benefits that hybrid brings, many defense organizations around world invest in development for combat vehicles develop prototypes tracked which have lower fuel consumption, better performance, exhaust emission, additional onboard electric power. However, v...