Near infrared photoimmunotherapy (NIR-PIT) is a newly-developed cancer therapy in which a monoclonal antibody is conjugated to a near-infrared photoabsorber, IR700 to form an antibody photoabsorber conjugate (APC). After the APC binds to cancer cells expressing the cognate antigen, exposure to NIR light results in rapid, highly selective necrotic cell death of the cancer cells with minimal off-...

BACKGROUND AND OBJECTIVE Humans are increasingly exposed to near-infrared (NIR) radiation from both natural (eg, solar) and artificial (eg, electrical appliances) sources. Although the biological effects of sun and ultraviolet (UV) exposure have been extensively investigated, the biological effect of NIR radiation is still unclear. We previously reported that NIR as well as UV induces photoagin...

The invasive nature and adverse side effects of surgery and chemotherapy have limited the efficacy of cancer treatment. Our laboratory has incorporated tissue penetrating near infrared (NIR) light and NIR-sensitive nanoparticles to develop a minimally invasive drug delivery system. NIR-activated release of an anticancer drug from NIR-sensitive nanoparticles could potentially reduce deleterious ...

In this paper, we report the use of lead sulfide quantum dot (PbS QD) bioconjugates as near infrared (NIR) contrast agents for targeted molecular imaging with expanded emission wavelengths beyond 1000 nm. The red-shifted emission band, coupled with the small particle size, which will facilitate clearance, both afford PbS QDs unique properties for noninvasive, high resolution in vivo NIR imaging...

The portable visible and near-infrared (NIR) imaging equipment for a pre-clinical test with small animals was designed and developed in this paper. The developed equipment is composed of a CCD camera, a focusing lens, an objective lens, a NIR band pass filter and a NIR filter driving motor. An NIR ray is mainly used for imaging equipment because it has high light penetration depth in biological...

We investigate the temporal behavior of flares in the NIR and millimeter regime of Sagittarius A*, the supermassive black hole in the Galactic center, observed on 2005 July 31 at the Keck II telescope, the Very Large Telescope, and the Submillimeter Array. The time lags between a VLT NIR flare and SMA millimeter flare as well as between three quasi-simultaneous Keck NIR flares are quantified th...

The physics behind the sometimes strange effects and ‘unnatural’ appearance of near-infrared (NIR) photographs is discussed in terms of reflection, absorption and transmission of NIR radiation with the respective objects. Besides discussing how NIR cameras work, several visible and NIR photograph pairs are presented, which include vegetation, natural water, clouds, the sky, and humans. In addit...

Novel strategies that target the epidermal growth factor receptor (EGFR) have led to the clinical development of monoclonal antibodies, which treat metastatic colorectal cancer (mCRC) but only subgroups of patients with increased wild type KRAS and EGFR gene copy, respond to these agents. Furthermore, resistance to EGFR blockade inevitably occurred, making future therapy difficult. Novel bio-im...

BACKGROUND The use of near-infrared (NIR) fluorescence imaging techniques has gained great interest for early detection of cancer owing to the negligible absorption and autofluorescence of water and other intrinsic biomolecules in this region. The main aim of the present study is to synthesize and characterize novel NIR fluorescent nanoparticles based on proteinoid and PLLA for early detection ...