Laparoscopic Nissen fundoplication has been applied with increasing frequency in the treatment of gastroesophageal reflux disease. The aim of this study was to determine the variables that predict outcome of laparoscopic Nissen fundoplication. A multivariate analysis was performed on data from 199 consecutive patients undergoing laparoscopic Nissen fundoplication. Variables included age, sex, b...

BACKGROUND Nissen Fundoplication is a common surgical procedure performed in treating gastroesophageal reflux disease (GERD). Complications include dysphagia, gastric hypersensitivity, abnormal gastric motility, gas bloat syndrome and GERD relapse. Dumping syndrome may occur when a large volume of gastric content is delivered to the duodenum or jejunum, resulting in both gastrointestinal and va...

An article by Nissen et al. in the November 2012 issue of GENETICS emphasizes the importance of alternative splicing in the sex determination cascade of the honeybee Apis mellifera. This study demonstrates the application of reverse transcriptase PCR and RNA interference screens as genetic tools to better understand the regulation of transcription and splicing. It also provides the opportunity ...

Postoperative herniation of the stomach into potential spaces is a rare but serious complication of Nissen fundoplication. We report a 55-year-old female who presented with persistent vomiting shortly following laparoscopic Nissen fundoplication. At laparotomy, the anterior wall of the stomach was noted to be herniating into a congenital space behind the diaphragm. Anterior gastropexy was perfo...

The mean metallicity of the Milky Way thin disc in the solar neighbourhood is still a matter of debate, and has recently been subject to upward revision (Haywood, 2001). Our star sample was drawn from a set of solar neighbourhood dwarfs with photometric metallicities. In a recent study, Reid (2002) suggests that our metallicity calibration, based on Geneva photometry, is biased. We show here th...

Suma Thomas, MD, MBA; Divyang Patel, MS; Barbara Bittel, BSN, RN; Kathy Wolski, MPH; Qiuqing Wang, Anirudh Kumar, Zachary J. Il’Giovine, MD; Reena Mehra, Carla McWilliams, Steve E. Nissen, Milind Y. Desai, MBA