Co-crystallization experiments of 4-halophenylboronic acid with several pharmaceutical compounds (including aciclovir, caffeine, nitrofurazone, and proline) produced new molecular complexes. The involved varying the solvent molar ratio boronic to a compound (e.g., 1:1, 2:1, 1:2). screening process for crystal phases revealed that formation different complexes was strongly influenced by presence...

The wound healing activity of cow urine was studied in Wistar albino rats. The efficacy of wound healing property was evaluated by excision wound model. The parameter studied was the rate of wound contraction. The studies on excision wound healing revealed that all the groups showed decreased wound area from day to day. On day 4th, the external application of urine showed significant increase i...

In this "Critical Review" we made a historical introduction of drugs assayed against Chagas disease beginning in 1912 with the works of Mayer and Rocha Lima up to the experimental use of nitrofurazone. In the beginning of the 70s, nifurtimox and benznidazole were introduced for clinical treatment, but results showed a great variability and there is still a controversy about their use for chroni...

OBJECTIVES The aim of this study was to design and evaluate a chitosan-based film that has properties required for successful wound dressing, and can control drug penetration and maintenance time in the location. METHODS Several formulations of a film containing chitosan (3%) and different concentrations of Eudragit RL (0.5%, 1%, and 1.5%) were prepared using the casting/solvent evaporating t...

The petroleum ether, chloroform, methanol, and aqueous extracts of Heliotropium indicum Linn. (Family: Boraginaceae) were separately evaluated for their wound healing activity in rats using excision (normal and infected), incision, and dead space wound models. The effects of test samples on the rate of wound healing were assessed by the rate of wound closure, period of epithelialisation, wound ...