CONTEXT Decompensated congestive heart failure (CHF) is the leading hospital discharge diagnosis in patients older than 65 years. OBJECTIVE To compare the efficacy and safety of intravenous nesiritide, intravenous nitroglycerin, and placebo. DESIGN, SETTING, AND PATIENTS Randomized, double-blind trial of 489 inpatients with dyspnea at rest from decompensated CHF, including 246 who received ...

In order to determine the severity of contraction abnormalities in acute myocardial infarction and their response to sublingual nitroglycerin, 23 patients were studied by radionuclide angiography within 6-24 hours after the onset of chest pain. Radionuclide angiograms were obtained in the right anterior oblique projection before and after nitroglycerin and segmental shortening was determined us...

Statins have been reported to show preventive effect on nitrate tolerance in normal rats, but there are no reports on their effect in diabetic animals. In this study, diabetes was induced in male wistar rats by a single intraperitoneal injection of streptozotocin (45 mg/kg). Five groups of diabetic and five groups of normal rats were treated; groups 1 (of normal and diabetic rats) received ator...

The possibility that nitroglycerin modifies the metabolic effects of the sympathominietic amines wits tested in cats. Changes in the heart rate, blood pressure, height of the electrocardiographic T-wave and myoctirdial oxygen consumption following the injection of epinephrine or 1-arterenol were compared with changes in these indices after nitroglycerin was given with these sympathomimetic amin...

Long-term nitroglycerin (NTG) therapy causes tolerance to its effects attributing to increased oxidative stress and endothelial dysfunction. Shenmai injection (SMI), which is clinically used to treat cardiovascular diseases, consists of two herbal medicines, Ginseng Rubra and Ophiopogonjaponicas, and is reported to have antioxidant effects. The present study was designed to investigate the pote...

BACKGROUND The treatment of unstable angina targets the specific pathophysiological thrombotic process at the site of the active culprit lesion. In unstable angina due to a restenotic lesion, smooth muscle cell proliferation and increased vasoreactivity may play a more important role than thrombus formation. Therefore, the relative benefits of nitroglycerin and heparin might differ in unstable ...

Platelet aggregation is currently felt to play an important role in the pathogenesis of ischemic vascular disorders. The smooth muscle relaxant, nitroglycerin, has been shown to inhibit platelet aggregation in vitro, but at concentrations that were felt to be unattainable in vivo. Because the in vivo action of nitroglycerin on smooth muscle cells has been shown to depend on the presence of redu...