BACKGROUND As previously various studies have suggested application of brain-derived neurotrophic factor (BDNF) may be considered as a promising future therapy for hearing deficits, in particular for the improvement of cochlear neurone loss during cochlear implantation. AIM The present study's aim was to establish the upper threshold of the concentration of BDNF in Naval Medical Research Inst...

Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of diabetic kidney disease. The actions of AGEs are mediated both through a non-receptor mediated pathway and through specific receptors for AGEs (e.g. RAGE). To explore a potentially specific role for RAGE in renal changes in type 1 diabetes, we examined the renal effects of a neutralising murine RAGE-antibody (ab) ...

UNLABELLED BACKGROUND DOR/TP53INP2 acts both at the chromosomal level as a nuclear co-factor e.g. for the thyroid hormone receptor and at the extrachromosomal level as an organizing factor of the autophagosome. In a previous study, DOR was shown to be down-regulated in skeletal muscle of obese diabetic Zucker fa/fa rats. METHODS To identify sites of differential DOR expression in metabolic...

nanotechnology researchers have identified a wide range of nanoparticle applications that may have an important role in medicine and treatment of diseases. due to lack of detailed documentation about the toxicology of zinc oxide (zno) nanoparticles, this study was aimed to evaluate the absorption of zno nanoparticles in hearts of female nmri mice. overall, 20 adult nmri female mice were studied...

The Composition of Streptomycin Reineckate: J. Fried and 0. Wintersteiner ............ .................. 273 Infrared Emission Spectra of Liquids: S. Frederick Kapff .... .................... 274 Dropping Device for Cylinder Plate Assay of Penicillin: Velma L. Chandler and Robert D. Shaw ...... 275 LETTERS TO THE EDITOR On Printing Wings of Insects for the Study of Venation: Darrell T. Sulliva...

Background: Nitric oxide (NO) is an important molecular regulator in biology of reproductive systems. In addition, critical level of NO is essential for Implantation and embryo’s development. However, increased levels of NO can have a wide range of adverse effects. This molecule is synthesized from L-Arginine (L.A) by Nitric oxide Synthetase (NOS) activity. In the current study, the effects of ...

The land surface phenology (LSP) start of season (SOS) metric signals the seasonal onset of vegetation activity, including canopy growth and associated increases in land-atmosphere water, energy and carbon (CO2) exchanges influencing weather and climate variability. The vegetation optical depth (VOD) parameter determined from satellite passive microwave remote sensing provides for global LSP mo...