In the light of relationships reported between hypoxemia (tissue hypoxia) and cancer, Abrams et al. concluded in 2008 that sleep apnea-hypopnea syndrome (SAHS) and its main consequence, intermittent hypoxia, could be related with increased susceptibility to cancer or poorer prognosis of a pre-existing tumor. This pathophysiological association was confirmed in animal studies. Two large independ...

Obstructive sleep apnea syndrome (OSAS) is a common pathology of the respiratory system characterized by upper airway blockage during sleep. The caused intermittent throat collapse and thereby no lung ventilation with preserved efforts. Earlier we demonstrated that telomeres at end chromosomes shorten nocturnal hypoxia fragmentation in OSA patients; elimination triggers contributed to an increa...

BACKGROUND Evidence suggests that recurrent nocturnal hypoxemia may affect pain response and/or the sensitivity to opioid analgesia. We tested the hypothesis that nocturnal hypoxemia, quantified by sleep time spent at an arterial saturation (SaO2) < 90% and minimum nocturnal SaO2 on polysomnography, are associated with decreased pain and reduced opioid consumption during the initial 72 postoper...

journal.publications.chestnet.org analyzed by a sleep medicine physician. 5 We have acknowledged the limitations of portable monitoring and the steps we took to minimize their potential impact on the study fi ndings, which we do not believe is signifi cant. We agree that well-designed, longitudinal studies are required to further evaluate the relationship between kidney function and the develop...

To understand animal ecology, observation of wildlife in the natural habitat is essential, but particularly challenging underwater realm. Weakly electric fishes provide an excellent opportunity to overcome some these challenges because they generate organ discharges (EODs) sense their environment and communicate, which can be detected non-invasively. We tracked EOD swimming activity two species...

There is a bidirectional, causal relationship between obstructive sleep apnea (OSA) and hypertension. OSA-related hypertension characterized by high rates of masked hypertension, elevated nighttime blood pressure, nondipper pattern nocturnal abnormal pressure variability. Hypoxia/hypercapnia-related sympathetic activation key pathophysiological mechanism linking the 2 conditions. Intermittent h...

Obstructive sleep apnea (OSA) is associated with recurrent episodes of nocturnal hypoxia and increased risk for development of systemic hypertension. Prior studies have been limited, however, in their ability to show reduction in blood pressure after continuous positive airway pressure (CPAP) therapy, and the effect of supplemental oxygen alone on blood pressure in OSA has not been evaluated. W...

OBJECTIVES We sought to determine the prevalence of nocturnal oxygen desaturation and obstructive sleep apnea (OSA) in a population of patients with hypertrophic cardiomyopathy (HCM). BACKGROUND The coexistence of sleep apnea and HCM, 2 common cardiovascular conditions, has been largely unrecognized in the treatment of patients with HCM. The nocturnal hypoxia-induced hyperadrenergic state in ...