Interferon-alpha (IFN-α) is an important mediator of antiviral immune responses. It is also used clinically in the treatment of hepatitis-C infection. Though effective, IFN-α-based therapies can often impair mood, motivation and cognition, which when severe can appear indistinguishable from major depression. In susceptible patients, fatigue and motivational impairment emerge early and have been...

Diffusion Magnetic Resonance Imaging (dMRI) is a powerful non-invasive and in-vivo imaging modality for probing brain white matter structure. Convolutional neural networks (CNNs) have been shown to be tool many computer vision problems where the signals are acquired on regular grid translational invariance important. However, as we considering dMRI that sphere, rotational invariance, rather tha...

As humans age, a characteristic pattern of widespread neocortical dendritic disruption coupled with compensatory effects in hippocampus and other subcortical structures is shown in postmortem investigations. It is now possible to address age-related effects on gray matter (GM) neuritic organization and density in humans using multishell diffusion-weighted MRI and the neurite-orientation dispers...

Diffusion MRI uses a multi-step data processing pipeline. With certain steps being prone to instabilities, the pipeline relies on considerable amounts of partly redundant input data, which requires long acquisition time. This leads to high scan costs and makes advanced diffusion models such as diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) inappl...