the main objective of present research work is to formulate the clopidogrel fast dissolving tablets. clopidogrel, an antiplatelet drug, belongs to bcs class-ii and used to control heart attack, hypertension by inhibiting platelet activation and aggregation .the fast dissolving tablets of clopidogrel were prepared employing different concentrations of crospovidone and croscarmellose sodium in di...

due to the fact that many application processes take place at different temperature, better examining and understanding of swelling properties as a function of temperature is essential for such application. the temperature effect on the swelling properties of commercial polyacrylic acid (paa) hydrogel beads was investigated as a function of time and temperature. gel bead size, swelling equilibr...

This paper presents a methodology for predicting moisture concentration in an epoxy adhesive under cyclic moisture absorption-desorption conditions. The diffusion characteristics of the adhesive were determined by gravimetric experiments under cyclic moisture conditions and the dependence of diffusion coefficient and saturated mass uptake on moisture history was determined. Non-Fickian moisture...

Objective(s): Polymeric nanofiber has a huge potential for a various biomedical applications such as wound healing and orthopedic implant. Since most of the future applications of therapeutic nanofiber are interacting with human blood components, it is important to investigate hemocompatibility. Methods: In this study, nanofibers with antibacterial properties were synthesizedby elec...

We examine a model for non-Fickian "sorption overshoot" behavior in diffusive polymer-penetrant systems. The equations of motion proposed by Cohen and White [SIAM J. Appl. Math., 51 (1991), pp. 472-483] are solved for two-dimensional problems using matched asymptotic expansions. The phenomenon of shock formation predicted by the model is examined and contrasted with similar behavior in classica...

The activity of cytarabine was decreased by its rapid deamination to the biologically inactive metabolite uracil arabinoside. This rapid deamination is the reason for the ongoing research for effective formulation of cytarabine that can not be deaminated and exhibit better pharmacokinetic parameters. Protection of cytarabine from fast degradation and elimination was investigated by encapsulatin...