Cisplatin is used to treat a variety of tumors, but dose-limiting toxicities or intrinsic and acquired resistance limit its application in many types of cancer including breast. Cisplatin was attached to silica nanoparticles using aminopropyltriethoxy silane as a linker molecule and characterized in terms of size, shape, as well as the dissolution of cisplatin from the silica surface. The prima...

Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a ...

The effects of silica nanoparticles on the properties of a commonly used Sylgard 184 polydimethylsiloxane (PDMS) in microfluidics were systemically studied. Two kinds of silica nanoparticles, A380 fumed silica nanoparticles and MCM-41 mesoporous silica nanoparticles, were individually doped into PDMS, and the properties of PDMS with these two different silica nanoparticles were separately teste...

Amorphous silica particles, whose applications are increasing in many biomedical fields, are known to be less toxic than crystalline silica. In this study, the inflammatory effects of amorphous silica nanoparticles were investigated using 30-nm amorphous silica nanoparticles and human peripheral blood mononuclear cells (PBMCs) or purified monocytes. As a result, production of IL-1β and IL-8 wer...

metal nanoshells consists of a dielectric core surrounded by a thin noble metal shell, possess unique optical properties that render nanoshells attractive for use in different technologies. this paper reports a facile method for growth of small gold nanoparticles on the functionalized surface of larger silica nanoparticles. mono-dispersed silica particles and gold nanoparticles were prepared by...

Novel bio-renewable castor oil based polyurethane (PU)-silica nanocomposite films were prepared using castor oil, 1,6-hexamethylene diisocyanate and dibutyltin dilaurate in tetrahydrofuran at room temperature. ATR-FTIR spectra confirm the formation of polyurethane and the presence of silica nanoparticles in the polyurethane matrix. The increase of Si nanoparticle content shifts the peak positio...

Bifunctional hairy silica nanoparticles (BHSNs), which are silica nanoparticles covered with alkyl and amino organic chains, were prepared as high-performance additives for lubricants. Compared with hairy silica nanoparticles covered by a single type of organic chain, binary hairy silica nanoparticles exhibit the advantages of both types of organic chains, which exhibit excellent compatibility ...

BACKGROUND The sentinel lymph node biopsy (SLNB) was developed as a new modality in the surgical diagnosis of lymph node metastases. Dye and radioisotope are major tracers for the detection of sentinel lymph nodes (SLN). Dye tends to excessively infiltrate into the interstitium due to their small size (less than several nanometers), resulting in difficulties in maintaining clear surgical fields...

Nanoparticles are one of the most important prominent areas in the field of nanotechnology, with a broad significant role in current life sciences and human healthcare applications. Among the nanoparticles silica nanoparticles are explored in many biological applications because their size dependent novel properties and functions differ drastically from those of the bulk materials. In biomedica...

in this work, the adsorption of the anionic dye, congo red (cr), from aqueous solution by using tea waste (tw) has been carried out at 30 °c. the equilibrium sorption isotherms and kinetics were investigated. the equilibrium adsorption was studied by the langmuir and freundlich models of adsorption. the experimental results manifested that the langmuir isotherm was the best model for the adsorp...