نتایج جستجو برای: nora efflux pump
تعداد نتایج: 79438 فیلتر نتایج به سال:
Multidrug resistance pumps (MDRs) protect microbial cells from both synthetic and natural antimicrobials. Amphipathic cations are preferred substrates of MDRs. Berberine alkaloids, which are cationic antimicrobials produced by a variety of plants, are readily extruded by MDRs. Several Berberis medicinal plants producing berberine were found also to synthesize an inhibitor of the NorA MDR pump o...
In the present study, a collection of 29 Gram-negative bacteria selected from organic foods according to antibiotics and biocide resistance were screened for multidrug efflux pumps and specific antibiotic resistance genes. The acrB pump gene of the AcrABeTolC system was detected in all isolates. EfrAB determinants efrA and efrB were frequently detected (Enterobacter, Pantoea, Salmonella), while...
Expression of bacterial efflux pump is one the major causes for developing antibiotic resistance in a variety pathogens. Efflux inhibitors (EPIs) are potential molecules that can antagonize those pumps and help alleviating problem. The study was aimed to explore EPI activity vitexin 2"-O-xyloside, an apigenin flavone glycoside. A total 15 clinical isolates Staphylococcus aureus were collected t...
The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist the action a wide range antibiotics is becoming growing problem for public health. search new compounds with potential help in reversion bacterial resistance plays an important role current medicinal chemistry research. Under this scope, efflux pumps are responsible antimicrobials, their inhibition coul...
Transport processes are used by all organisms to obtain essential nutrients and to expel wastes and other potentially harmful substances from cells. Such processes are important means by which resistance to selected antimicrobial agents in bacteria is achieved. The recently described Staphylococcus aureus norA gene encodes a membrane-associated protein that mediates active efflux of fluoroquino...
Alpha-tocopherol is one the most abundant and biologically active isoforms of vitamin E. This compound is a potent antioxidant and one of most studied isoforms of vitamin E. Vitamin D3 (cholecalciferol) is an important nutrient for calcium homeostasis and bone health, that has also been recognized as a potent modulator of the immune response. Methicillin-resistant Staphylococcus aureus (MRSA) i...
legionella pneumophila is the pathogen responsible for severe pneumonia known as legionnaires’ disease. legionella can live under varied stress conditions, especially in cold environments, and is common in many artificial environments. in this study, the antimicrobial activity of biogenic silver nanoparticles, prepared using the culture supernatant of klebsiella pneumoniae, was evaluated agains...
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