background: osteoclastogenesis is coordinated by the interaction of members of the tumor necrosis factor (tnf) superfamily: receptor activator of nuclear factor-κb ligand (rankl) and osteoprotegerin (opg). the aim of this study was to compare the effect of two different types of non-steroidal anti-infl ammatory drugs (nsaids) on the rankl/opg balance during the healing of the alveolar process. ...

Nearly identical cells can exhibit substantially different responses to the same stimulus. We monitored the nuclear localization dynamics of nuclear factor κB (NF-κB) in single cells stimulated with tumor necrosis factor-α (TNF-α) and lipopolysaccharide (LPS). Cells stimulated with TNF-α have quantitative differences in NF-κB nuclear localization, whereas LPS-stimulated cells can be clustered i...

Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various biological processes, including immune response, inflammation, cell growth and survival, and development. NF-κB is critical for human health, and aberrant NF-κB activation contributes to development of various autoimmune, inflammatory and malignant disorders including rheumatoid arthritis, atherosclerosis, ...

8-Prenylkaempferol (8-PK) is a prenylflavonoid isolated from Sophora flavescens, a Chinese herb with antiviral and anti-inflammatory properties. In this study, we investigated its effect on regulated activation, normal T cell expressed and secreted (RANTES) secretion by influenza A virus (H1N1)-infected A549 alveolar epithelial cells. Cell inoculation with H1N1 evoked a significant induction in...

Gastrointestinal neoplasia seems to be a common consequence of chronic inflammation in the gastrointestinal epithelium. Nuclear factor-kappaB (NF-κB) is an important transcription factor for carcinogenesis in chronic inflammatory diseases and plays a key role in promoting inflammation-associated carcinoma in the gastrointestinal tract. Activation of NF-κB is regulated by several posttranslation...

Nuclear factor-κB (NF-κB) is important in inflammatory skin diseases, including contact dermatitis (Th1 inflammation), atopic (Th2 and psoriasis (Th17 inflammation). In fact, molecularly targeted drugs against tumor necrosis factor (TNF), which both upstream downstream of NF-κB have been demonstrated to be effective diseases such as psoriasis. The linear ubiquitination by ubiquitin chain assemb...

Protein overload activates proximal tubule epithelial cells (PTECs) to release chemokines. Bone morphogenetic protein-7 (BMP-7) reduces infiltrating cells and tissue damage in acute and chronic renal injuries. The present study examines the inhibitory effect and related molecular mechanism of BMP-7 on chemokine and adhesion molecule synthesis by PTECs activated with human serum albumin (HSA). T...

The transcription factor nuclear factor-κB (NF-κB) is crucial for the maintenance of homeostasis. It is incompletely understood how nuclear NF-κB and the crosstalk of NF-κB with other transcription factors are controlled. Here, we demonstrate that the epigenetic regulator histone deacetylase 2 (HDAC2) activates NF-κB in transformed and primary cells. This function depends on both, the catalytic...

To reveal the effects of Oldenlandia diffusa (OD) on relieving progression and development gestational diabetes mellitus (GDM), explore underlying mechanism. A rat model GDM was established by streptozotocin injection. The OD rats were evaluated measuring levels fasting blood glucose (FBG), insulin, hemoglobin A1c (HbA1c), exposing to oral tolerance test (OGTT) histological evaluation pancreas....

Selective expression of dominant negative (DN) peroxisome proliferator-activated receptor γ (PPARγ) in vascular smooth muscle cells (SMC) results in hypertension, atherosclerosis, and increased nuclear factor-κB (NF-κB) target gene expression. Mesenteric SMC were cultured from mice designed to conditionally express wild-type (WT) or DN-PPARγ in response to Cre recombinase to determine how SMC P...