as described in the first part of this article, evidence based medicine (ebm) is a growing part of medical practice which emphasizes on the best evidence. finding this evidence by formulating an answerable question and searching strategies were described in the first part of this review. in this part, appraising the retrieved article (with the main focus on the diagnostic studies) and applying ...

Context: Recently, new anti-epileptic drugs are marketed to be used as an add-on to the traditional drugs in children with refractory epilepsy. Levetiracetam is a second-generation of new anti-epileptic drugs with unknown precise mechanism of action in brain and synaptic vesicle in children with drug resistant epilepsy. Herein, the efficacy and safety of add-on levetiracetam in children with re...

Refractory epilepsy is common in practice of neurology. Dyke-Davidoff-Masson Syndrome (DDMS) is one among the syndromes associated with refractory epilepsy. We have come across a case of Dyke-Davidoff-Masson syndrome while investigating a case of refractory epilepsy. When cerebral hemi atrophy is associated with the radiological features of osseous hypertrophy of calvarium, hyper-pneumatisation...

Abstract Aim A third of epilepsy patients suffer from medically refractory seizures. In eligible for surgical treatment, seizure freedom rates remain variable. Machine learning (ML) utilises large datasets to detect patterns make predictions. We systematically review studies employing ML models prediction outcome following resective surgery evaluate their efficacy, applicability and value in de...

BACKGROUND Febrile seizures are the most common seizure disorder in childhood, associated with a significant rise in body temperature. However, post-infectious refractory afebrile form of seizures in previously healthy children is being increasingly recognized in around the world, which evolves into a chronic refractory form of epilepsy. The term 'Febrile infection-related epilepsy syndrome' (F...

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BACKGROUND Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infantile spasms (IS), seizure other than IS, refractory epilepsy, Lennox-Gastaut ...

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Hemozoin Detection for Human Malaria Diagnosis Investigated in Rodent Models: How Similar Is Similar? Hanscheid, Thomas ; Carvalho, Tânia ; Grobusch, Martin P. TRENDS IN PARASITOLOGY. Vol. 32. Edição: 2. pp. 94-96 DOI: 10.1016/j.pt.2015.11.012. Fev. 2016 Texto integral 24-hour rhythmicity of seizures in refractory focal epilepsy Nzwalo, Hipólito ; Cordeiro, Inês Menezes ; Santos, Ana Catarina ;...

Refractory Epilepsy (R.E.) is a condition where all antiepileptic drugs (AEDs) fail to provide adequate seizure control. To diagnose R.E., false cases of refractoriness need to be carefully excluded. There are several predictors of refractoriness. The treatment options in R.E. are resective surgery, ketogenic diet and vagal nerve stimulation. The roles of newer AEDs are also promising. The futu...