Loss of nerve cells from temporal cortex, hippocampus, nucleus basalis of Meynert and locus caeruleus was measured in 32 patients with Alzheimer's disease ranging from 48 to 92 years of age. Similar changes were present within the cerebral cortex and within the two subcortical structures.

Amyloid-beta (Abeta) is toxic to neurons and such toxicity is - at least in part - mediated via the NMDA receptor. Calpain, a calcium dependent cystein protease, is part of the NMDA receptor-induced neurodegeneration pathway, and we previously reported that inhibition of calpain prevents excitotoxic lesions of the cholinergic nucleus basalis magnocellularis of Meynert. The present study reveals...

some animal models have been used to study alzheimer's disease (ad). ad is an irreversible progressive neurodegenerative disease and the most common cause of dementia. animal studies have shown that there is a relation between decrease in cholinergic functions in the nucleus basalis of meynert (nbm) and loss of learning capability and memory. the aim of this study was to investigate the ef...

AI primary auditory cortex AC auditory cortex BDA biotinylated dextran amines BF best frequency CNC cochlear nuclear complex CNIC central of the inferior colliculus DCN dorsal cochlear nucleus DCIC dorsal cortex of the inferior colliculus DNLL dorsal nucleus of the lateral lemniscus DSCF Doppler-shifted constant frequency ECIC external cortex of the inferior colliculus ES electrical stimulation...