نتایج جستجو برای: nucleus pulposus

تعداد نتایج: 112028  

Journal: :Journal of Biomechanics 2012

Journal: :THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 1987

Journal: :Arthritis Research & Therapy 2008
Tomoko Nakai Joji Mochida Daisuke Sakai

INTRODUCTION Although transforming growth factor beta1 (TGFbeta1) is known to be a potent inhibitor of proliferation in most cell types, it accelerates proliferation in certain mesenchymal cells, such as articular chondrocytes and nucleus pulposus cells. The low ability for self-renewal of nucleus pulposus cells is one obstacle in developing new therapeutic options for intervertebral disc disea...

Journal: :Revista brasileira de ortopedia 2010
André Luiz de Souza Grava Luiz Fernando Ferrari Carlos Amílcar Parada Helton Luiz Aparecido Defino

UNLABELLED To evaluate the hyperalgesia and histological abnormalities induced by contact between the dorsal root ganglion and the nucleus pulposus. METHODS Twenty Wistar rats were used, divided into two experimental groups. In one of the groups, a fragment of autologous nucleus pulposus was removed from the sacrococcygeal region and deposited on the L5 dorsal root ganglia. In the other group...

Journal: :Genetics and molecular research : GMR 2015
J W Wu J J Wang J B Chen Y L Huang H Wang G H Liu L F Li M Kang X G Wang H H Cai

Intervertebral disc degeneration is the main cause of lumbago disease, in which the extracellular matrix structure and moisture in the nucleus pulposus is lost continuously. In this study, we aimed to detect differential expression of silence mating type information regulation 2 homolog 1 (SIRT1) and matrix metalloproteinase-1 (MMP-1) in human intervertebral disc nucleus pulposus cells and to e...

Journal: :Journal of Biological Chemistry 1967

Journal: :Acta Orthopaedica Scandinavica 1951

Journal: :Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2009
Gang Feng Yuqing Wan Francis H Shen Xudong Li

Many of the therapeutic interventions for intervertebral disc degeneration attempt to repopulate the nucleus pulposus (NP) tissue; however, NP cells are heterogeneous and not well characterized. To address this, we have investigated the morphology, extracellular gene and protein expression, and apoptosis changes in NP explants cultured in vitro with or without chondrogenic reagents for differen...

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