There are great expectations regarding the potential contribution of integrated care interventions to improved outcomes, but so far the evidence is mixed. In this dissertation, we focussed on why, when and how some integrated care interventions contribute to improved outcomes, while others do not. To this purpose, we developed the COMIC Model for studying the Context, Outcomes and Mechanisms of...

Predictor-corrector (PC) methods for the numerical solution of stiff ODEs can be extended to include the second derivative of the solution. In this paper, we consider second derivative PC methods with the three-step second derivative Adams-Bashforth as predictor and two-step second derivative Adams-Moulton as corrector which both methods have order six. Implementation of the proposed PC method ...