Over the last two decades, deep brain stimulation has become widely accepted as a treatment for Parkinson’s disease, dystonia and tremor, and its use is increasing in disorders such as obsessivecompulsive disorder, depression and pain. The primary objective is always to achieve symptom suppression with few or no side effects; in other words, to attain as wide a therapeutic window as possible. I...

In this issue of JMCP, Faresjö and colleagues found that 13.3% of patients with irritable bowel syndrome (IBS) reported using antidepressants versus 4.5% of control patients without IBS.1 The more than 3-fold higher use of antidepressants (odds ratio [OR] = 3.27, 95% confidence interval [CI] = 2.27-4.70) among patients with IBS is not a surprising finding, but the actual use of drugs by IBS pat...

for both the orbits. A quick neurologic examination revealed a completely delirious state; initial orbital ultrasonography showed collapsed ocular coats without visible contents/foreign body, subsequent computed tomography of the head and orbit showed no visible globe in either of the orbits with soft tissue edema (Figure 2). There was no evidence of intracranial bleed or major organ damage and...

291 Selected by experts as the treatment of choice for youngsters, cognitive-behavioral therapy (CBT) has emerged as a safe, viable, and effective treatment for obsessivecompulsive disorder (OCD) among children and adolescents. Yet, most children with OCD do not receive CBT, at least in part due to the shortage of clinicians who are well versed in managing the unique challenges that arise in th...

This month's CNS Spectrums examines cholinergic mechanisms of cognitive dysfunction in schizophrenia, how attention-deficit/hyperactivity disorder (ADHD) may complicate the course of other psychiatric illness, whether serotonin reuptake inhibitors (SRIs) may induce spontaneous abortions, treatment-resistant obsessivecompulsive disorder (OCD), and how silent brain lesions can present as psychiat...

Objective: The aim of the current study was to investigate the role of fusion beliefs and metacognitions in obsessive–compulsive symptoms in the general population. Methods: A sample of 200 students of Kharazmi University was selected from various faculties and completed the following questionnaires: Metacognitions Questionnaire-30 (MCQ-30), Thought-Fusion Instrument (TFI) and Maudsley Obses...

objective: the aim of the current study was to investigate the role of fusion beliefs and metacognitions in obsessive–compulsive symptoms in the general population. methods: a sample of 200 students of kharazmi university was selected from various faculties and completed the following questionnaires: metacognitions questionnaire-30 (mcq-30), thought-fusion instrument (tfi) and maudsley obsessiv...

1479 In the late 1980s, studies of children with Sydenham chorea (SC), the neurological manifestation of rheumatic fever, suggested that the disorder might serve as a useful model of pathophysiology for some forms of childhood-onset obsessivecompulsive disorder (OCD) and tic disorders. The disorders share anatomic similarities. Both OCD and SC have evidence of basal ganglia dysfunction, particu...

cells, are similarly present on some Tregs. As a result, Tregs home to the same regions in inflamed organs as their proinflammatory targets to control exuberant immune responses. This notion is suggested by several studies in the recent years13,14; however, Eller et al.1 did not find Tregs in inflamed kidneys of wild-type animals. This observation is surprising because it contradicts previous s...

Historically, obsessions and compulsions have been mentioned in the religious and nonscientific literature for centuries. Obsessivecompulsive features are not only present in individuals, but constitute an important part of collective rituals and ceremonies including magic and superstition (Meyer, 1968). The purpose of this paper will be focused on the medical aspects of obsessions and compulsi...