background: in several conditions we have face cranial bone defects. reconstruction of these defects remains one of the most challenging problems encountered by craniofacial surgeons.   objective: to evaluate bone repair in cranial bone defects by use of an implant made of octacalcium phosphate in combination with bone matrix gelatin (ocp/bmg).   methods: we used 40, 5–6-week-old male sprague-d...

statement of problem: it is not known whether endochondral and intramembranous bones have distinct biological characteristics. octacalcium phosphate (ocp), a hydroxyapatite precursor, has been reported to stimulate bone formation after being implanted in parietal bone defects of rats. purpose: the present study was designed to investigate the response of endochondral and intramembranous bones t...

INTRODUCTION This in vitro study assessed and compared the cytotoxicity of mineral trioxide aggregate (MTA), calcium-enriched mixture (CEM) cement, Biodentine (BD) and octacalcium phosphate (OCP) on stem cells of the human apical papilla (SCAP). METHODS AND MATERIALS SCAPs were isolated from two semi-impacted third molars. The cells were cultured in wells of an insert 24-well plate and were t...

Cementum protein 1 (CEMP1) has been recently cloned, and in vitro experiments have shown functions as regulator of cementoblast behavior and inducer of differentiation of non-osteogenic cells toward a cementoblastic/osteoblastic phenotype. In this study, we have produced a full-length human recombinant CEMP1 protein in a human gingival fibroblast cell line. The purified protein (hrCEMP1) has a ...

The promising future of calcium phosphates (CaP) as a group of biomedical materials with a wide range of functions, might ultimately depend on tuning their composition and microstructure. However, the disorderly growth and aggregation of CaP nanocrystals limit their practical application. This paper reports a strategy for designing polypeptide/trace elements (TE), dual mediating the self-assemb...

Bone grafts used in alveolar bone regeneration can be categorized into autografts, allografts, xenografts, and synthetic bones, depending on their origin. The purpose of this study was to evaluate the effect a commercialized octacalcium phosphate (OCP)-based substitute material (Bontree®) vitro, vivo, clinical cases. Material characterization Bontree® granules (0.5 mm 1.0 mm) using scanning ele...

This study aimed at preparing and studying the properties of nanoparticles of calcium phosphate (nCaP) with Ca/P ratios ranging from 1.0 to 1.67 using a spray-drying technique. Micro-structural analyses suggested that the nCaPs with Ca/P ratios of 1.67 to 1.33 were nano-sized amorphous calcium phosphate (ACP) containing varying amounts of acid phosphate and carbonate. The nCaP with Ca/P ratio o...

It was demonstrated that octacalcium phosphate collagen composite achieved notable bone regeneration in bone defects in preclinical studies. On the basis of the research results, an investigator-initiated exploratory clinical trial was conducted after approval from a local Institutional Review Board. This clinical study was performed as a single-arm non-randomized intervention study. Octacalciu...

The surfaces of hydoxyapatite ceramics were modified by the precipitation of octacalcium phosphate coating from aqueous solution and the biomimetic method synthesized nanohydroxyapatite coatings. Both coatings were deposited as continuous and uniform layers. It was demonstrated that the octacalcium phosphate coating was inappropriate for in-vitro osteoblast proliferation despite of good initial...