IN a paper on" Certain abnormal conditions of the macular region usually classed as colobomata," which appeared in this journal in *March, 1927, an attempt was made to classify congenital defects in the neighbourhood of the posterior pole and to provide some diagnostic points by means of which a rough idea of the time of origin and the mechanism of production of the abnormality might be gained....

The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis. Several transcription factors and signaling pathways have been shown to be important for RPE maintenance and differentiation, but an understanding of the initial fate specification and determination of this ocular cell...

Previously used methods of comparing amperometric spike characteristics from two separate groups of cells have entailed pooling all the values for a spike characteristic from each group of cells and then statistically comparing the two samples. Although this approach has indicated that there are significant differences between the spike characteristics from coloboma and control mouse chromaffin...

Sporadic colobomata may be associated with a variety of secondary changes, and these have been classified and discussed with special reference to unusual findings published during recent years. Clinically some cases may appear to be neoplastic, and pathological examination may be important in demonstrating their true nature. A malformation apparently not previously reported is described.

purpose: to evaluate the outcomes and complications of phacoemulsification and posterior chamber intraocular lens implantation (pe+pciol) in patients with congenital iris coloboma. methods: in a prospective noncomparative interventional case series, 13 eyes of 9 patients (six female and three male) with congenital iris coloboma and cataract underwent pe+pciol using clear corneal incision and in...

The optic vesicle comprises a pool of bi-potential progenitor cells from which the retinal pigment epithelium (RPE) and neural retina fates segregate during ocular morphogenesis. Several transcription factors and signaling pathways have been shown to be important for RPE maintenance and differentiation, but an understanding of the initial fate specification and determination of this ocular cell...

CLINICAL CASE This was a 15-month-old boy who had macular retinochoroidal lesions in both eyes following maternal varicella during pregnancy. DISCUSSION The scars were suggestive of congenital chorioretinal infection, but because of negative serology and the clinical picture, we believe the problems are atypical macular colobomata.

(Figure 2). The mean±SD thickness of the retina at the site of the cleavages was 106.4±17.7 m and that of the adjacent unaffected retina was 254.2±25.8 m. The mean thickness of the retina at the site of the cleavages was significantly thinner than that of the adjacent unaffected retina (P .001, Mann-Whitney U test). The fluorescein angiograms showed no abnormalities. The results of standard aut...