Eye is the most vital organ of the body. To achieve effective ocular therapy, an adequate amount of active ingredients must be delivered and maintain at the site of action within the eye. The anatomical structure and the protective physiological process of the eye exert a formidable defense against ophthalmic drug delivery, leads to poor precorneal drug loss results in poor ocular by availabili...

Drug therapy intervention plays a major role in the management of many ocular diseases. However, precise delivery of pharmaceutical solutions to a specified target within the body is an ongoing challenge in many areas of drug delivery. Current routes of ocular treatment (topical, systemic or intraocular injections) have limited efficacy due to physiological barriers, potential side effects, and...

To my dearest parents For their love, trust and supports ACKNOWLEGMENT I would like to thank my advisor, my thesis committee members, my research colleagues, my family and my friends who made this thesis possible. I would like to thank my thesis advisor, Mark Prausnitz for his support during my thesis work. Without his guidance, it would be difficult for me to complete my study. I would like to...

Aschottana is one of the speciality procedures among kriyakalpas in which herbal medications form liquid are instilled into conjunctival sac, drop by at a distance 2 angulas called as Aschottana. Ocular drugs usually delivered locally to eye. Required drug loading, release rate, and ocular retention time delivery systems depend on potency, bioavailability, clearance target site. The concept exp...