Calcifying odontogenic cyst (COC) is an odontogenic cyst with accumulation of ghost cells that has central and peripheral subsets. Here, we present an 11-year-old male patient with an intraoral swelling on the left posterior mandibular ridge interfering with eruption of the second molar. Histopathologic examination revealed a cystic lesion lined by ameloblast-like epithelium in the basal layer ...

Carcinoma arising primarily from the jaw is a locally aggressive lesion with poor prognosis. Primary intraosseous carcinoma (PIOC) lesion develops either de novo remnants of odontogenic epithelium, odontogenic cyst/tumor, epithelium remnants, or/and salivary gland residues. We describe very interesting case of primary intraosseous carcinoma of mandible. This extensive lesion was sent for oncolo...

OKC has been of special interest because of aggressive behavior, specific histopathological features, and high recurrence rate.4 The WHO has designated keratocyst OKC as a keratocystic odontogenic tumor because of its neoplastic nature and defined as a benign unior multicystic intraosseous tumor of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epitheliu...

Ameloblastic fibrosarcoma (AFS) or ameloblastic sarcoma is an extremely rare odontogenic neoplasm. The authors report AFS in the maxillary sinus of a 4-month-old boy. The tumor was composed of odontogenic epithelium, resembling that of ameloblastoma, and a mesenchymal part exhibiting features of fibrosarcoma. We also found some areas with deposition of dentinoid material closely adjacent to the...

Midkine (MK; a low molecular weight heparin-binding growth factor) is a multifunctional cytokine. MK plays a role in morphogenesis of many organs including teeth through epithelial-mesenchymal interactions. We immunohistochemically examined MK expression in various human odontogenic tumors. There was no difference in positive rate and intensity of MK between benign odontogenic tumors and their ...

The molecular events of odontogenic induction are beginning to be elucidated, but until now nothing was known about the molecular basis of the patterning of the dentition. A role for Dlx-1 and Dlx-2 genes in patterning of the dentition has been proposed with the genes envisaged as participating in an 'odontogenic homeobox gene code' by specifying molar development. This proposal was based on th...

Background. Calretinin is a 29 kDa calcium-binding protein of the EF-hand family which is expressed in a variety of normal and tumorigenic tissues. Its expression in odontogenic epithelium during odontogenesis and in neoplastic odontogenic tissues has been demonstrated. Unicystic ameloblastoma poses a diagnostic challenge, as its histologic presentation can be sometimes mistaken for keratocysti...

Ameloblastoma is a true neoplasm of odontogenic epithelial origin. It is the second most common odontogenic neoplasm, and only odontoma outnumbers it in reported frequency of occurrence. Its incidence, combined with its clinical behavior, makes ameloblastoma the most significant odontogenic neoplasm. Unicystic ameloblastoma (UA) refers to those cystic lesions that show clinical, radiographic, o...

Odontogenic cysts and tumors originate from remnants of odontogenic epithelium and have a wide spectrum of histopathologic and clinical characteristics, ranging from benign non-invasive to locally invasive or malignant lesions. Histopathologic similarities between these lesions may challenge the correct diagnosis, especially in small size specimens, and may also lead to unnecessary broad surger...

The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the ...