Abnormal pancreatic beta cell function is known to occur in type 2 diabetes mellitus. However, direct measurement of pancreatic beta cell function is cumbersome and virtually out of reach of most laboratories in developing countries. Fortunately, insulinogenic indices may be used as surrogate measures of beta cell function. To study insulinogenic indices among type 2 diabetic Nigerians. A cross...

Diabetes is growing public health. The research investigated the modulatory roles of aqueous stem-bark extract Moringa oleifera on glucose utilization. A modified Oral Glucose Tolerance Test (OGTT) was used in studying effect absorption, four groups six rats and standard methods were to test enzyme activities (hexokinase 6 phosphatase) three rats. In OGTT, group-1(diabetic control) group-4 (nor...

Objectives: To determine the chronic complications of diabetes mellitus (DM) in patients with prediabetes, and to compare prediabetics normoglycemic group participants terms presence DM. Methods: An observational study was conducted between December 2018 April 2019. The aged 18-65 years were recruited from an internal medicine outpatient clinic a tertiary care hospital. A total 106 prediabetic ...

We read with interest the article by Boronat et al. (1). In that article, individuals with discordant diabetes status by A1C and oral glucose tolerance test (OGTT) had their cardiovascular risk profile evaluated. Those who fulfilled the A1C-based criterion presented greater measures of BMI and waist circumference and lower values for HDL cholesterol than individuals with diabetic OGTT but A1C,6...

Rationale. Cystic fibrosis related diabetes (CFRD) is the most common comorbidity in patients with CF. In spite of increased screening, diagnosis, and treatment of CFRD, the mortality rate in patients with CFRD still far exceeds the mortality rate in those without CFRD. Guidelines suggest that screening for CFRD be performed annually using the 2-hour 75-gram oral glucose tolerance test (OGTT). ...

BACKGROUND Type 2 diabetes (T2D) is associated with substantial morbidity and mortality. Individuals with a family history of T2D are at an increased risk of developing the disease. The aim of this study was to assess metabolic differences between first-degree relatives (FDR) of T2D patients and persons with no known family history of T2D (non-FDR). METHODS In 200 FDR and 73 non-FDR, we compa...

The oral glucose tolerance test (oGTT) is a common tool to provoke a metabolic challenge for scientific purposes, as well as for diagnostic reasons, to monitor the kinetics of glucose and insulin. Here, we aimed to follow the variety of physiological changes of the whole metabolic pattern in plasma during an oGTT in healthy subjects in a nontargeted reversed-phase ultra performance liquid chrom...

INTRODUCTION A diagnosis of gestational diabetes mellitus (GDM) in low-risk pregnant women is based on an oral glucose tolerance test (OGTT) between 24 and 28 gestational weeks. However, there is insufficient evidence for why the test is performed in this time period. Moreover, the fetus may be exposed to hyperglycaemia prior to the current testing time frame, making earlier administration pote...

Results Overall, 26 individuals had prediabetes, 28 did not have prediabetes (22 had 1h-OGTT>fasting glycemia, 6 had 1h-OGTT≤fasting glycemia) and 5 had diabetes. The 1h-OGTT≤fasting glycemia and diabetes groups were excluded, and then a non-parametric test (Mann-Whitney U test) was used to analyze data. There were no statistical differences between 1h-OGTT>fasting glycemia and prediabetes grou...

Hyperlipidemia (HLP) is characterized by a disturbance in lipid metabolism and is a primary risk factor for the development of insulin resistance (IR) and a well-established risk factor for cardiovascular disease and atherosclerosis. The aim of this work was to investigate the changes in postprandial amino acid and biogenic amine profiles provoked by an oral glucose tolerance test (OGTT) in HLP...