BACKGROUND The aim of the study was to elucidate whether leukotriene receptor antagonists (LTRAs) can prevent severe allergic reactions, which occur during oral immunotherapy (OIT) in children with food allergies. FINDINGS Five children with food allergies [3 allergic to hen's egg (HE), 1 to wheat, and one to cow's milk (CM); aged between 7 and 12 years; median, 8.5 years] who were started on...

We consider the problem of classifying peptides using the information residing in their syntactic representations. This problem, which has been studied for more than a decade, has typically been investigated using distance-based metrics that involve the edit operations required in the peptide comparisons. In this paper, we shall demonstrate that the Optimal and Information Theoretic (OIT) model...

Background One of the most promising therapies in persistent and severe food allergy is oral immunotherapy (OIT), with immediate goal of desensitization and long-term goal of tolerance. However, a subgroup of patients may experience severe allergic reactions. These concerns might be addressed by combination of OIT with another promising therapy involving anti-IgE monoclonal antibodies (omalizum...

Methods We study 23 children with CMA that met the following criteria: clinical history of IgE-mediated CMA in the last 6 months and specific IgE (sIgE) for cow’s milk (CM) ≥ 15 kU/L (> 2 years) or ≥ 5 kU/L (< 2 years). On study entry, basal serum levels for sIgE for CM and casein plus sIgG4 for casein were obtained. The study was divided into 2 stages. In the first 12 months, patients were ran...

Methods Prospective longitudinal epidemiological intervention study. Egg-allergic children aged 5–18 underwent a Spanish-approved egg-OIT protocol without premedication. Clinical data, skin prick test (SPT) and specific IgE (sIgE) at baseline and 9 months after OIT were registered. All dose-related reactions, treatments needed and cofactors involved were recorded. Through survival analysis, we ...

Food allergy is a major public health problem in children, impacting upon the affected individual, their families and others charged with their care, for example educational establishments, and the food industry. In contrast to most other paediatric diseases, there is no established cure: current management is based upon dietary avoidance and the provision of rescue medication in the event of a...

Planet Oit is a multi-user virtual environment used to teach geologic concepts and the scientific method. It is built on a structured system of modules and goals arranged so that students have freedom, but have direction as well. Intelligent software tutors explain geologic concepts, guide the players in achieving their goals, and assist them in understanding the environment. Planet Oit and its...

Methods 63 peanut allergic children (median: age 6 years; peanutspecific IgE 73,5kU/l) who participated in an oral immunotherapy (OIT)-study were enrolled. Data concerning age of diagnosis, provision with self-injectable epinephrine, professional advice and performance of a peanut-free diet as well as the characterization of accidental allergic reactions to peanut (grade of severity I-V) were c...

Background Egg allergy is one of the most common food allergies in childhood with an estimated prevalence of 2.6 %. Oral immunotherapy (OIT) appears as a promising approach to induce egg-tolerance. However, the immune mechanisms underlying this treatment are not completely known. The purpose of the study was to compare the immune responses against egg allergens of a pediatric population under a...

Early breast milk, known as colostrum ("liquid gold") provides immune benefits to infants, offering potential risk reduction for nosocomial infection (NI) and necrotizing enterocolitis (NEC), a serious gastrointestinal emergency. Provision of colostrum is recognized as oral immune therapy (OIT) and is valuable to all NICU infants unable to feed orally. A quality improvement project was initiate...