Oleic acid is a common pharmaceutical excipient that has been widely used in various dosage forms. Gas chromatography (GC) has often been used as the quantitation method for fatty acids normally requiring a derivatization step. The aim of this study was to develop a simple, robust, and derivatization-free GC method that is suitable for routine analysis of all the major components in oleic acid ...

The uptake of C-labeled oleic acid and its incorporation into combined lipids by aortic intimas from normal and cholesterol-fed rabbits has been investigated in vitro. More than five times as much oleic acid was taken up by the atherosclerotic intima as by the normal intima. About twice as much oleic acid was incorporated into phospholipid, and twenty times as much into cholesterol ester by the...

Zinc oxide nano-particles with the average diameter of about 25 nm were modified with different mole ratios of trimetoxyvinyl silane (TMVS) and oleic acid, as coupling agents, in order to modify their surface properties and render them more hydrophobic. Then, dispersibility of the surface modified nano-particles was examined in some monomers with different levels of hydrophobicity, including me...

Ani M1, Moshtaqi AA1, Ahmadvand H2 1. Assistant Professor, Department of Clinical Biochemistry, Faculty of pharmacy, Isfahan University of Medical Sciences 2. Assistant Professor, Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences Abstract Background: There are reports indicating that fatty acid transport is affected by many biochemical paramete...

The oxidation of organic films on cloud condensation nuclei has the potential to affect climate and precipitation events. In this work we present a study of the oxidation of a monolayer of deuterated oleic acid (cis-9-octadecenoic acid) at the air-water interface by ozone to determine if oxidation removes the organic film or replaces it with a product film. A range of different aqueous sub-phas...

The current study has examined whether drugs that are transported to the systemic circulation via the intestinal lymph (and therefore associate with lipoproteins within the enterocyte) are accessible to enterocyte-based metabolic processes. The impact of changes to the mass of lipid present within the enterocyte-based lymph lipid precursor pool (LLPP) on the extent of enterocyte-based drug meta...

Binding of 13C-enriched oleic acid to bovine serum albumin and to three large proteolytic fragments of albumin--two complementary fragments corresponding to the two halves of albumin and one fragment corresponding to the carboxyl-terminal domain--yielded unique patterns of NMR resonances (chemical shifts and relative intensities) that were used to identify the locations of binding of the first ...

Introduction. Edible oils containing > 60 % monoenoic acids (i. e. oleic acid), in particular olive oil and Canola oil have been shown to exhibit beneficial effects on lipid metabolism in human (LDL-cholesterol blood levels, triacylglycerol blood levels) within the last few years [1]. These findings are in contrast to earlier recommandations by nutrition experts who strongly favored high-linole...

Obese hypertensive patients with cardiovascular risk factor clustering have increased plasma nonesterified fatty acid levels and are at high risk for atherosclerotic events. Our previous studies demonstrated that oleic acid induces a mitogenic response in rat aortic smooth muscle cells (RASMCs) through protein kinase C (PKC)- and extracellular signal-regulated kinase (ERK)-dependent pathways. I...