Thiophene oligomer nanoparticles (NPs) were studied by fluorescence spectroscopy and electrogenerated chemiluminescence (ECL). Distinct spectroscopic differences between aggregates or NPs of thiophene hexamers having differing substitution patterns of solubilizing alkyl groups were observed. The α,ω-unsubstituted thiophene hexamer, Hexamer-2, exhibited fluorescence properties that were similar ...

In this minireview, we survey recent advances in the synthesis, characterization, and modeling of new oligothiophene-oligopeptide hybrids capable of forming nanostructured fibrillar aggregates in solution and on solid substrates. Compounds of this class are promising for applications because their self-assembly and stimuli-responsive properties, provided by the peptide moieties combined with th...

Aggregates of misfolded proteins play an important role in diseases such as Alzheimer's. Here it is demonstrated how the anionic oligothiophene p-FTAA interacts with and influences pre-fibrillar protein assemblies during the earlier stages of in vitro fibrillation. Conjugated polythiophenes have previously been demonstrated to detect and discriminate between different types of protein aggregate...

Deposits comprised of amyloid-β (Aβ) are one of the pathological hallmarks of Alzheimer's disease (AD) and small hydrophobic ligands targeting these aggregated species are used clinically for the diagnosis of AD. Herein, we observed that anionic oligothiophenes efficiently displaced X-34, a Congo Red analogue, but not Pittsburgh compound B (PIB) from recombinant Aβ amyloid fibrils and Alzheimer...

We have investigated, using atomistic molecular dynamics simulations, the high temperature molecular organization of the linear oligothiophene α-sexithienyl (T6), well known for its organic electronics applications. We have found a smectic and a nematic liquid crystalline phase in the same temperature range where they had been experimentally reported but not fully characterized. We have microsc...

Density functional theory calculations together with highly resolved gas-phase ultraviolet photoelectron spectroscopy have been applied to oligothiophene chains with up to eight thiophene rings. One of the important parameters governing the charge transport properties in the condensed phase is the amount of energy relaxation upon ionization. Here, we investigate the impact on this parameter of ...

The electrooxidation of a,c~'-coupled thiophene oligomers alkyl-protected toward anodic coupling at the terminal c~ positions was studied in solid state at room temperature. Reversible oxidation goes from a single one-electron step oxidation for the tetramers to two separate oneelectron steps for the pentamer and hexamer. The oxidation potentials are found to be primarily dependent on the conju...