Knowledge Embedding in the Description System Omega Carl Mewitt, 6iuseppe Attardi, and Maria Simi M.I.T. 545 Technology Square Cambridge, Mass 02139 Omega is a description system for knowledge embedding which combines mechanisms of the predicate calculus, type systems, and pattern matching systems. It can express arbitrary predicates (achieving the power of the o-order quantificational calculus...

Non-homologous end joining (NHEJ) is a major DNA double strand breaks (DSBs) repair pathway that maintains genome integrity. However, this pathway may reduce radiotherapy efficacy by repairing DSBs on cancer cells. This research reported a computer-aided drug design (CADD) method to identify novel inhibitors from traditional Chinese medicine (TCM) that disrupt NHEJ. We aim to inhibit Ku86, the ...

Assuming the conventional Casimir setting with two thick parallel perfectly conducting plates of large extent with a homogeneous and isotropic medium between them, we discuss the physical meaning of the electromagnetic field energy W disp when the intervening medium is weakly dispersive but nondissipative. The presence of dispersion means that the energy density contains terms of the form d[ome...

Abstract. Stationary, long-lasting blocked weather patterns can lead to extreme conditions such as anomalously high temperatures or heavy rainfall. The exact locations of extremes depend on the location vortices that form block. There are two main types blocking: (i) a high-over-low block with located poleward an isolated low and (ii) omega lows lie southeast southwest blocking in Northern Hemi...

X-linked adrenoleukodystrophy (X-ALD) is a severe neurodegenerative disorder biochemically characterized by elevated levels of very long-chain fatty acids (VLCFA). Excess levels of VLCFAs are thought to play an important role in the pathogenesis of X-ALD. Therefore, therapeutic approaches for X-ALD are focused on the reduction or normalization of VLCFAs. In this study, we investigated an altern...

Transcription in vitro of stringently controlled Escherichia coli genes by purified RNA polymerase holoenzyme is inhibited by guanosine tetraphosphate (ppGpp). In order to examine possible role of omega factor in this ppGpp sensitivity, RNA polymerases with or without the omega factor were reconstituted and tested for their ppGpp sensitivity using an in vitro mixed transcription system. RNA pol...

We have studied the dynamic scanning of liquid-crystalline (LC) poly(p-phenyleneterephthalamide) sulfuric acid (PPTA-H(2)SO(4)) solution, and its blend with single-walled carbon nanotubes (SWNTs), by using a flat plate rotational rheometer. The effects of weight concentration and molecular weight of PPTA, as well as operating temperature, on dynamic viscoelasticity of the PPTA-H(2)SO(4) LC solu...

We consider a harmonic chain of $N$ oscillators in presence disordered magnetic field. The ends the are connected to heat baths and we study effects field randomness on transport. disorder, general, causes localization normal modes due which system becomes insulating. However, for this system, length diverges as mode frequency approaches zero. Therefore, low contribute transmission, $\mathcal{T...