BACKGROUND Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased om...

BACKGROUND Omeprazole is metabolized predominantly by CYP2C19, a polymorphically expressed enzymes that show marked interindividual and interethnic variation. These variations cause a substantial differences that have been reported in the pharmacokinetics of omeprazole. The aim of the present study was to evaluate the pharmacokinetic parameters of omeprazole in a random Iranian population. ME...

BACKGROUND Gastric and duodenal bacterial overgrowth frequently occurs in conditions where diminished acid secretion is present. Omeprazole inhibits acid secretion more effectively than cimetidine and might therefore more frequently cause bacterial overgrowth. AIM This controlled prospective study compared the incidence of gastric and duodenal bacterial overgrowth in patients treated with ome...

Colitis-associated cancers arise in the setting of chronic inflammation wherein an "inflammation-dysplasia-carcinoma" sequence prevails. Based on our previous findings in which the proton pump inhibitor could impose significant levels of anti-inflammatory, antiangiogenic, and selective apoptosis induction beyond gastric acid suppression, we investigated whether omeprazole could prevent the deve...

The aim of this study was to evaluate the contribution of metabolites to drug-drug interactions (DDI) using the inhibition of CYP2C19 and CYP3A4 by omeprazole and its metabolites as a model. Of the metabolites identified in vivo, 5-hydroxyomeprazole, 5'-O-desmethylomeprazole, omeprazole sulfone, and carboxyomeprazole had a metabolite to parent area under the plasma concentration-time curve (AUC...

Objectives This prospective study assessed the effectiveness and patient satisfaction of four-week omeprazole therapy in acid peptic disease (APD). Methods was an observational, post-marketing, real-world evidence, patient-reported outcome (PRO) measures study. Patients visiting five sites across India with symptoms APD, who were prescribed oral (20/40 mg per day) for at least four weeks enroll...

Jul 1, 2011 . The oral acid suppressors famotidine and omeprazole have been widely used. To facilitate dosing, the omeprazole paste was combined with . with H2RAs, such as ranitidine or famotidine, 30–60 minutes prior to a meal would be a standard dose omeprazole, pantoprazole, or lansoprazole in more. Feb 25, 2015 .

BACKGROUND A neutral gastric pH is critical for the stability of clots over bleeding arteries. We investigated the effect of preemptive infusion of omeprazole before endoscopy on the need for endoscopic therapy. METHODS Consecutive patients admitted with upper gastrointestinal bleeding underwent stabilization and were then randomly assigned to receive either omeprazole or placebo (each as an ...

About 1.5-6 % of the patients with gastric and duodenal erosions admitted to I.C.U. are prone to gastrointestinal (G.I.) bleeding with its ensuing complications. Routine prophylaxis with H2-blockers and anti-acid has been used in these high risk patients for decades.In this study we evaluated the effect of P.O omeprazole, a potent acid inhibitor with prolong effects on gastric pH.  Patients wit...

BACKGROUND Proton pump inhibitor and histamine-2 receptor antagonist can prevent aspirin-related ulcers/erosions but few studies compare the efficacy of these two agents. Aims. We evaluated the efficacy of omeprazole and famotidine in preventing recurrent ulcers/erosions in low-dose aspirin users. METHODS The 24-week clinical outcomes of the patients using low-dose aspirin for cardiovascular ...