BACKGROUND To determine whether gadolinium-based contrast media (CM) could be used safely for angiographies in patients with renal dysfunction we investigated renal function after gadobutrol exposure and compared the results with standard iodinated CM (iohexol) in a randomized clinical study. METHODS Twenty-one patients (aged 67+/-11 years, nine female and 12 male) with severely impaired rena...

A 41 year old man presented with a three month history of chest pain, decreased effort tolerance, and haemoptysis. A chest radiograph suggested a large cavitating neoplasm replacing the entire left upper lobe and diffuse opacification of the remaining lung on that side. Other investigations were non-contributory. Rigid bronchoscopy identified the presence of blood within the orifice of the left...

Background. Thrombotic complications occurring during coronary angiography and percutaneous transluminal coronary angioplasty (PTCA) are relatively frequent and can be influenced by the type of radiographic contrast media used. Low osmolar contrast media (LOCM), both ionic and nonionic, have been considered to be safer than the older high osmolar contrast media (HOCM), causing less haemodynamic...

BACKGROUND Thrombotic complications occurring during coronary angiography and percutaneous transluminal coronary angioplasty (PTCA) are relatively frequent and can be influenced by the type of radiographic contrast media used. Low osmolar contrast media (LOCM), both ionic and nonionic, have been considered to be safer than the older high osmolar contrast media (HOCM), causing less haemodynamic ...

A 69-year-old woman with a history of atypical chest pain was referred for coronary computed tomographic (CT) angiography study with a 64-detector row multidetector CT scanner (LightSpeed VCT, GE Healthcare, Milwaukee, Wis). Imaging was performed after multiphasic injection of nonionic contrast media (Omnipaque 350, GE Healthcare) into the right antecubital vein at a rate of 4.0 mL/s through a ...

Aims: In the present study we tested the efficacy of N-acetylcysteine (NAC) to minimize nephrotoxic effects of iodine contrast agents in intact rats as well as in 5/6-nephrectomized (5/6-Nx) rats. Methods: Rats were allocated to a group of intact rats (n = 42) and a group of 5/6-Nx rats (n = 42). After 1 month of recovery from surgery, 5/6-Nx rats and intact (sham-operated) animals received eit...

BACKGROUND Contrast induced nephropathy (CIN) is the commonest cause of iatrogenic renal injury and its incidence has increased with the advent of complex endovascular procedures. Evidence suggests that ascorbic acid (AA) has a nephroprotective effect in percutaneous coronary interventions when contrast media are used. A variety of biomarkers (NGAL, NGAL:creatinine, mononuclear cell infiltratio...

To the Editor: We report an incident of an allergic reaction to a small dose of intraarterial nonionic contrast material that was administered during cerebral angiography in a patient premedicated with steroids and antihistamines. A 23-year-old man with epilepsy was referred for cerebral angiography and Wada testing. These were performed for the purpose of language and memory testing before tem...

At present, the largest group of radiopaque contrast agents (RCA) is represented by iodinecontaining RCA. However, the development of abdominal interventional X-ray surgery places stringent requirements upon RCA. High contrast must be combined with pharmacological and physiological inertness, low toxicity, with the ability to be uniformly adsorbed as a thin layer on the surface of mucous organs...

Dear Editor, Phacoemulsification in eyes with scarred corneas is challenging and due to the poor surgical view, carries an increased risk of complications. 1 In healthy eyes, the cornea is transparent due to the small diameter, and relatively regular size and spacing of stromal collagen fibrils, in addition to similarity of the refractive indices of collagen fibrils (1.411) and the extrafibrill...