Cervical cancer is a female-specific disease with a high incidence and mortality. MicroRNAs (miRNAs) are implicated in posttranscriptional regulation of gene expression and in the pathogenic mechanisms of cancer, suggesting their importance in diagnosis and treatment. miRNAs may have roles in the pathogenesis of cervical cancer based on the increases or decreases in several specific miRNAs foun...

Viruses disrupt the host cell microRNA (miRNA) network to facilitate their replication. Human T-cell leukemia virus type I (HTLV-1) replication relies on the clonal expansion of its host CD4(+) and CD8(+) T cells, yet this virus causes adult T-cell leukemia/lymphoma (ATLL) that typically has a CD4(+) phenotype. The viral oncoprotein Tax, which is rarely expressed in ATLL cells, has long been re...

Lymphoma with secondary central nervous system (CNS) involvement have poor prognosis and high mortality. Its diagnosis is based on conventional methods low sensitivity and/or specificity. MicroRNAs are short post-transcriptional gene regulators that remarkably stable detectable extracellularly in body fluids. We analyzed circulating microRNAs the cerebrospinal fluid (CSF) plasma of 162 patients...

Background: Colorectal Cancer (CRC) is the most common malignant gastrointestinal cancer. stem cells (CSCs) are major cause of cancer recurrence and drug resistance. Silibinin, as an herbal compound, has anticancer properties. Objectives: The present study aimed to evaluate antiproliferative effects silibinin on HT29 stem-like (spheroids). Methods: In this study, apoptotic properties Silibinin ...

Despite recent advancement in medicine, nearly 50% of patients with colorectal cancer show recurrence of the disease. Although the reasons for the high relapse are not fully understood, the presence of chemo- and radiotherapy-resistant cancer stem/stem-like cells, where many oncomirs like microRNA-21 (miR-21) are upregulated, could be one of the underlying causes. miR-21 regulates the processes...

BACKGROUND MicroRNA (miRNA) is a short and endogenous RNA molecule that regulates posttranscriptional gene expression. It is an important factor for tumorigenesis of colorectal cancer (CRC), and a potential biomarker for diagnosis, prognosis, and therapy of CRC. Our objective is to identify the related miRNAs and their associations with genes frequently involved in CRC microsatellite instabilit...