Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synthesis of 3,4,5-substituted furan-2(5H)one derivatives via a one-pot three-component reaction of arylamines, aromatic aldehydes and dialkyl acetylenedicarboxylates in water. This method has notable advantages in terms of simple workup, no need for column chromatography, short reaction time and high y...

Maltose as an efficient, available, cheap and eco-friendly catalyst has been applied for the synthesis of 3,4,5-substituted furan-2(5H)one derivatives via a one-pot three-component reaction of arylamines, aromatic aldehydes and dialkyl acetylenedicarboxylates in water. This method has notable advantages in terms of simple workup, no need for column chromatography, short reaction time and high y...

BACKGROUND The classical Strecker reaction is one of the simplest and most economical methods for the synthesis of racemic α-aminonitriles (precursor of α-amino acids) and pharmacologically useful compounds. RESULTS Indium powder in water is shown to act as a very efficient catalyst for one-pot, three-component synthesis of α-aminonitriles from diverse amines, aldehydes and TMSCN. This genera...

Three-component reactions have emerged as useful methods because the combinationof three components to generate new products in a single step is extremely economical,among the multi-component reactions. A green, simple, efficient, and cost-effective procedure has been carried out by the synthesis of dihydropyrimidinonesin Biginelli’s condensation of ethyl cyanoacetate, aldehyde and urea or thio...

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