Activity-guided fractionation of a petroleum ether-soluble extract of the roots of Onosma paniculata, which has been shown to affect the cell cycle and to induce apoptosis in melanoma cells, led to the isolation of several shikonin derivatives, namely, β-hydroxyisovalerylshikonin (1), acetylshikonin (2), dimethylacrylshikonin (3), and a mixture of α-methylbutyrylshikonin and isovalerylshikonin ...

Aysun TOKER*, Fatih AKÇAY, Hülya AKSOY, Halis SÜLEYMAN, Ufuk ÖZGEN, Havva ERDEM 1 Department of Biochemistry, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey 2 Department of Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey 3 Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey 4 Department of Pharmacognosy, Faculty of ...

The aim of this study was to investigate the antioxidant properties root extract Onosma armeniacum and its cytotoxic effect against human liver (HepG2), lung (A549) colon (WiDr) cancer cell lines compared with a normal fibroblast line. Antioxidant determined using colorimetric methods. were investigated MTT assay. total phenolic content reducing power values 26.1±0.4 mg gallic acid equivalent 5...

A new species of Onosma L. (Boraginaceae: Lithospermeae), from the Hakkari province eastern Turkey, is described and illustrated. The endemic distributed in a narrow area Sat Mountains. Taxonomically closest relative satensis sp. nov. O. polioxantha Rech. f. which also occurs Turkey. In addition, it primarily distinguished by its navicular leaves, longer reticulate cauline pedicels calyx, dense...

consists of 85 species, occurring mainly in Iran and westward to Syria, Turkey and Europe. It is represented in Pakistan by 8 species. Onosma hispida WALL. is a perennial herb up to 70 cm tall with a prominent taproot, it is widely distributed in the northern areas of Pakistan. The plant has cooling, laxative, anthalminitic and alexipharmic effects, and is also used to treat diseases of the eye...