background: fecal calprotectin (fc) has been suggested as a noninvasive substitute marker to determine the degree of intestinal inflammation in patients with inflammatory bowel disease (ibd). the aim of this study was to compare fc levels in ibd and irritable bowel syndrome (ibs), to show its discriminative value and relationship with clinical disease activity in patients with ibd. materials an...

background : there is an association   of celiac disease (cd) with several gastrointestinal illnesses. we aimed to determine   the prevalence of cd in patients with inflammatory bowel disease (ibd) to evaluate the value of the routine serological tests for cd in these patients. methods : patients with ibd underwent   screening test for cd. the screening test was based on iga anti-ttg antibody e...

Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant an...

AIM To identify simple, objective, accurate histological criteria for distinguishing acute infective-type colitis, chronic idiopathic inflammatory bowel disease, and irritable bowel syndrome on rectal biopsy in patients with acute onset diarrhoea at first presentation, one to 10 weeks after onset. METHODS Cell counts and measurements of mucosal architecture were made on initial rectal biopsie...

Numerous environmental factors have been linked with inflammatory bowel disease. These include smoking, diet, hygiene, drugs, geographical and psychosocial factors. These factors may either increase the risk of or protect against developing this condition and can also affect the course of illness in a positive or negative manner. A number of studies have examined the influence of environmental ...

Inflammatory bowel disease is a heterogeneous group of chronic disorders that result from the interaction of the intestinal immune system with the gut microbiome. Until recently, most investigative efforts and therapeutic breakthroughs were centered on understanding and manipulating the altered mucosal immune response that characterizes these diseases. However, more recent studies have highligh...