Opiate reward memories are powerful triggers for compulsive opiate-seeking behaviors. The basolateral amygdala (BLA) is an important structure for the processing of opiate-related associative memories and is functionally linked to the mesolimbic dopamine (DA) pathway. Transmission through intra-BLA DA D1-like and D2-like receptors independently modulates the formation of opiate reward memories ...

Purpose. The objective of this study was to document the number of controlled substance prescriptions filled by adolescents and young adult patients in the 2 years prior to presentation for opiate dependence treatment. Methods. Opiate-dependent youth (N = 125) presenting to our Medication-Assisted Treatment for Addiction program from January 1, 2008 to June 30, 2010 were identified via electron...

MAIN RESULTS Fourteen RCTs (n=848) met inclusion criteria: alcohol dependence, eight RCTs; methadone maintained opiate dependence, four RCTS; cocaine dependence, two RCTs. Antidepressants produced a clinically significant response in 52% compared with 38% placebo (percentage difference 16.8%, 95% CI 6.9% to 26.7%). Antidepressants produced a pooled effect size for the Hamilton Depression Scale ...

OBJECTIVE To evaluate the Structured Interview for Tanning Abuse and Dependence (SITAD). DESIGN Longitudinal survey. SETTING College campus. PARTICIPANTS A total of 296 adults. MAIN OUTCOME MEASURES The SITAD modified items from the Structured Clinical Interview for DSM-IV Axis I Disorders that focus on opiate abuse and dependence. Indoor tanning (IT) behavioral patterns and opiate-like...

BACKGROUND Despite the importance of heavy drinking and alcohol dependence among patients with opiate and cocaine dependence, few studies have evaluated specific interventions within this group. The aim of the present study was to evaluate the impact of screening with the Alcohol Use Disorders Identification Test (AUDIT) and of brief intervention (BI) on alcohol use in a sample of patients trea...

OBJECTIVE To compare IGF1 levels in opiate dependent and general patients both absolutely and by age. DESIGN A naturalistic observational study was undertaken of opiate dependent and general medical patients. SETTING Primary care. PATIENTS 74 opiate substance use dependent (SUD) patients were compared with 262 non-SUD (NSUD) patients. RESULTS (1) Comparative IGF1 levels; (2) age and sex...

Opiate dependence and withdrawal have long been hypothesized to enhance the reinforcing effects of opiates; however, opiate agonist self-administration in these states has yet to be systematically assessed. To address this issue, the reinforcing property of the short-acting -opioid agonist, remifentanil, was assessed in morphine-dependent (MD), morphine-dependent and -withdrawn (MW), and nondep...

INTRODUCTION Recent studies (Gold et al, 1978; Washton et al, 1980a) showing that the non-opiate antihypertensive agent, clonidine hydrochloride, suppresses signs and symptoms of opiate withdrawal, have suggested that clonidine and similar drugs might be useful in the clinical management of opiate detoxification. The fact that clonidine is not an opiate drug and does not itself produce addictio...