BACKGROUND We assessed the analgesic efficacy of parecoxib, acetaminophen, and the combination of both compared with placebo in patients undergoing elective thyroid or parathyroid surgery. METHODS We randomized 140 patients to receive one of the following i.v. treatments using a double-blinded double-dummy technique: placebo, 80 mg 24 h(-1) parecoxib, 5 g 24 h(-1) acetaminophen, or 80 mg pare...

Mu opioid (MOP) agonists acting in the nucleus accumbens (NAcc) robustly enhance consumption of palatable foods. In addition, the effect on consumption of palatable foods produced by MOP agonists acting in the NAcc depends on both recent flavor exposure and the availability of a choice between different-flavored foods. In contrast, kappa opioid (KOP) agonists have variable effects on feeding an...

BACKGROUND This prospective double-blinded, randomized controlled trial compared adductor canal block (ACB) with femoral nerve block (FNB) in patients undergoing total knee arthroplasty. The authors hypothesized that ACB, compared with FNB, would exhibit less quadriceps weakness and demonstrate noninferior pain score and opioid consumption at 6 to 8 h postanesthesia. METHODS Patients received...

Background Posterior spinal fusion treatment is one of the most painful options accessible to teenagers with idiopathic scoliosis.Objectives This study evaluated opioid-sparing anesthesia analgesic effect using a combination dexmedetomidine, ketamine and lidocaine versus opioid-based (OBA) fentanyl in adolescent patients undergoing scoliosis surgery.Methods prospective, double-blinded, randomiz...

Pain after total abdominal hysterectomy (TAH) is a major concern. Pain management is very important issue after TAH. This study aimed to assess the efficacy of intraperitoneal instillation of lidocaine for postoperative pain relief after TAH. A double-blinded randomized placebo-controlled trial was conducted on patients undergoing total abdominal hysterectomy in Al-zahra hospital from June 2007...

PURPOSE Low-dose naltrexone (LDN) is used in a wide range of conditions, including chronic pain and fibromyalgia. Because of the opioid antagonism of naltrexone, LDN users are probably often warned against concomitant use with opioids. In this study, based on data from the Norwegian prescription database, we examine changes in opioid consumption after starting LDN therapy. METHODS We included...

Abstract Opioids are one of the effective forms analgesia for acute pain in perioperative period but, with overprescription, have become detrimental to public health. There has been a steady increase opioid consumption and number opioid-related deaths, U.S. government declared epidemic as health emergency. Anesthesiologists responsibility first exposure opioids was during majority cases. Acute ...

conclusions the study results demonstrated that preemptive use of dextromethorphan reduced postoperative pain and opioid consumption. patients and methods this double blind randomized clinical trial was conducted on arthroscopic surgery candidates. participants were randomly allocated to interventions and assigned to two groups of dextromethorphan and placebo. in dextromethorphan group, the pat...