PURPOSE To investigate the magnification characteristic of the +90-D double-aspheric fundus examination lens for biomicroscopic measurement of the optic disc. METHODS A calibrated Gullstrand-type model eye adjusted for axial ametropia between -12.5 and +12.6 D was used to measure the change in magnification of the system with refractive error and variation in fundus lens position. A correctio...

A 74-year-old man presented to the ophthalmology outpatient clinic with reduced visual acuity and increasing haziness of vision in his left eye over several months. Seven years previously he had undergone uneventful cataract surgery with phacoemulsification and insertion of a posterior chamber lens (+14.5 dioptres Alcon MA60BM, 6.0 mm optic) in the same eye. There had been no postoperative comp...

A new, single-piece, hydrophobic acrylic lens - the first constructed with a lens optic and haptics comprised of a hydroxyethyl methacrylate-polyethylene glycol phenyl ether acrylate-styrene copolymer, cross-linked with ethylene glycol dimethacrylate, and labeled as "glistening-free" - was recently introduced globally. Glistenings have been a significant source of clinical concern with previous...

Embryonic chick cells of the presumptive lens ectoderm are induced to differentiate into a lens by the optic vesicle, an outgrowth from the developing brain. This lens induction involves formation of the lens placode by cell elongation between about 44 and 50 hr of development, followed by invagination of the placode between about 50 and 55 hr of development. The amount of delta-crystallin mess...

purpose : to report two patients with spontaneous scleral perforation and bleb formation associated with marfan syndrome (mfs) which one of them also showed bilateral optic nerve dural ectasia. case reports : an 11-year-old girl was referred with progressive myopia. past medical history was negative. slit-lamp examination revealed bilateral scleral thinning and perforation with bleb formation, ...

A 39-year-old man with pathologic myopia and a dislocated native lens of the right eye underwent pars plana lensectomy and implantation of an iris-fixated 3-piece MA60MA foldable acrylic intraocular lens with -5.0 diopter power. The patient presented 11 months later with spontaneous haptic disinsertion from the optic. The meniscus (concave-convex) configuration of this iris-fixated lens may hav...

PURPOSE To investigate in vitro how the posterior convexity of an intraocular lens (IOL) affected the migration of lens epithelial cells (LECs) under its optic. METHODS Porcine LECs were cultured for 9 days with polymethylmethacrylate (PMMA) IOLs in a cell culture chamber insert containing a collagen membrane on which the IOLs were implanted. The central sagittal optic depths of the implanted...

The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologs, Mab21l1 and Mab21l2, have been identified in many species. We describe the generation of Mab21l1-deficient mice with defects in eye and preputial gl...

The Pax6 transcription factor plays a key role in ocular development of vertebrates and invertebrates. Homozygosity of the Pax6 null mutation in human and mice results in arrest of optic vesicle development and failure to initiate lens formation. This phenotype obscures the understanding of autonomous function of Pax6 in these tissue components and during later developmental stages. We employed...

introduction: among the components of the extracellular matrix (ecm) and basement membrane (bm), laminitis heterotrimeric glycoprotein (laminin) and collagen type iv are the most important. in a previous study we have examined the role of collagen type iv in the developing lens capsule. the present study aims to determine the appearance and distribution of laminin in the bm and ecm of lenses du...