PURPOSE To determine whether inducible nitric oxide synthase (NOS-2) is involved in glaucomatous optic neuropathy. METHODS Chronic elevation of rat intraocular pressure (IOP) leading to optic nerve damage was induced by episcleral injection of hypertonic saline, which caused sclerosis and blockade of aqueous humor outflow pathways. Expression of NOS-2 in the retina and optic nerve head (ONH) ...

Metrizamide is a water-soluble, nonionic radiocontrast medium that penetrates better into narrow subarachnoid spaces than do oily contrast media or gas. We performed metrizamide optic nerve thecography on five cats with iatrogenic orbital lesions. Optic thecograms successfully demonstrated displacement of the optic nerve, obstruction of the optic nerve sheath subarachnoid space, and extravasati...

PURPOSE To use magnetic resonance imaging (MRI) to measure the diameter along the course of the intraorbital optic nerve in living subjects and cadaveric specimens, and to validate measurements histologically in the same specimens. METHODS Measurements of the intraorbital optic nerve were made in 23 living human subjects and in three formalin-fixed orbits using high-resolution, surface coil M...

NERVE fibre bundles of different size aberrant ,from the optic nerve escape according to Ida Mann (1937) from the confines of the optic stalk, and become free in the orbit. They originate at an early stage (about 17 mm. length) when the nerve fibres find their way from the ganglion cells into the optic stalk. Anatomically they are a division of the main stem of the optic nerve in its orbital or...

BACKGROUND AND PURPOSE MR imaging characteristics of optic neuropathy caused by cat scratch disease have not yet been described; this lack of information may result in incorrect diagnosis and may contribute to initiation of inappropriate therapy. Our study was based on the hypothesis that cat scratch disease-related optic neuropathy has distinct MR imaging features compared with those of other ...

PURPOSE To describe the arterial blood supply, capillary bed, and venous drainage of the rat optic nerve head. METHODS Ocular microvascular castings from 6 Wistar rats were prepared by injection of epoxy resin through the common carotid arteries. After polymerization, tissues were digested with 6 M KOH, and the castings washed, dried, and coated for scanning electron microscopy. RESULTS Imm...

Cranial computed tomographic scans of 225 patients with orbital mass lesions were reviewed. In 11 patients, the optic nerve was seen as a linear defect through the orbital mass. These 11 cases comprised three optic nerve sheath meningiomas, three hemangiomas, two cases of pseudotumor, and one case each of Erdheim-Chester disease, optic neuritis, and metastatic disease. Optic nerve sheath mening...