PURPOSE To investigate the effect of bilberry extract anthocyanins on retinal ganglion cell (RGC) survival after optic nerve crush. Additionally, to determine details of the mechanism of the neuroprotective effect of bilberry extract anthocyanins and the involvement of endoplasmic reticulum stress suppression in the mouse retina. MATERIALS AND METHODS Anthocyanins in bilberry extract (100 mg/...

Purpose: To review primary literature on ocular and orbital injury secondary to all-terrain vehicles (ATVs). Methods: A Medline search of English language literature. Results: Very few studies detail ocular and orbital manifestations of ATV crashes. The most common ocular injuries included orbital fractures and eyelid lacerations. Less common but more severe injuries included traumatic optic ne...

Traumatic blindness is a well recognized entity with a guarded prognosis. Previous studies have variously reported the incidence of concomitant optic canal fractures and response to surgical therapy. With the advent of CT scanning, a new technique for study of these severely injured patients has become available. Over a period of 20 months, optic foramen fractures were demonstrated in 10 such p...

excessive scarring; paralleling the process in tendon reconstruction of the hand. inspired by the advantages of the two-stage technique in tendon grafting and with encouraging preliminary results, we aimed to investigate the two-stage nerve grafting technique as an alternative method of secondary nerve repair. methods:  thirty female rats (~200 g) were randomly distributed into two groups (n=15...

Objective-  To determine the possibility of three-dimensional ultrasonography (3DUS) and measurement of optical nerve sheet by this method. Design- Descriptive study. Animals- 10 mixed normal dogs (5males, 5 females), age 1-1.5 year, and weighting 15±5 kg Procedure- 3D ultrasounds of the eyes were evaluated and the normal optical nerves in 3DUS images were measured using Volouson 730 pro....

Strategies to improve function after CNS injuries must contend with the failure of axons to regrow after transection in adult mammals. In this issue of Neuron, Smith et al. provide an important advance by demonstrating that SOCS3 acts as a key negative regulator of adult optic nerve regeneration.

Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve head plays a major role. Rodent models to study glaucoma include those that mimic either ocular hypertension or optic nerve injury. Here we re...

Ophthalmic artery is the branch of internal carotid artery as it emerges from the cavernous sinus medial to anterior clinoid process. Thereafter it traverses in optic canal to enter in the orbit, lies inferolaterally to the optic nerve. It continues forward over the optic nerve (80%) and below the nerve (20%). Main trunk of the artery ends by dividing in to supratrochlear and dorsal nasal branc...

Inducible heat shock proteins (Hsps) are upregulated in the central nervous system in response to a wide variety of injuries. Surprisingly, however, no coherent picture has emerged regarding the magnitude, duration and cellular distribution of inducible Hsps in the visual system following injury to retinal ganglion cells (RGCs). The current study sought, therefore, to achieve the following two ...

INTRODUCTION Avulsion of the optic nerve head is a rare and severe complication of ocular blunt trauma. The case reported is a 28-year old man presenting to the emergency department due to blunt trauma to his right eye globe with a tree branch. Lid haematoma and subconjunctival haemorrhage were present. Visual acuity soon after the injury was counting fingers (CF) and on admission to the Depart...