conclusions this study suggests that decrease in levels of tlr3 and tlr7 expression is a mechanism that may enable hcv to evade the host innate immune response. results in both groups, we had 13 males and 12 females with a mean age of 48.7 ± 16. tlr3 (6.23 ± 0.91 vs. 3.89 ± 0.85, p < 0.001) and tlr7 (1.48 ± 0.82 vs-1.33 ± 1.18, p < 0.001) expressions were significantly lower in patients with ch...

We study a robust toll pricing problem where toll setters and users have different level of information when taking their decisions. Toll setters do not have full information on the costs of the network and rely on historical information when determining toll rates, whereas users decide on the path to use from origin to destination knowing toll rates and having, in addition, more accurate traff...

In obese adipose tissue, Toll-like receptor signaling in macrophages leads to insulin resistance in adipocytes. Similarly, Toll signaling in the Drosophila larval fat body blocks insulin-dependent growth and nutrient storage. We find that Toll acts cell autonomously to block growth but not PI(3,4,5)P3 production in fat body cells expressing constitutively active PI3K. Fat body Toll signaling bl...

The congestion pricing has been discussed as a practical tool for traffic management on urban transport networks. The traffic congestion is defined as an external diseconomy on the network in transport economics. It has been proposed that the congestion pricing would be used to reduce the traffic on the network. This paper investigates the cordon-based second-best congestion-pricing problems on...

This paper uses an analytical-simulation model to examine the optimal extent and welfare effects of pricing reforms for passenger transportation in Mexico City. The model incorporates travel by auto, microbus, public bus, and rail, plus externalities from local and global air pollution, traffic congestion, and road accidents. In our benchmark case, the optimal gasoline tax is $2.72 (29.6 pesos)...

1 We extend the existing toll pricing studies with fixed demand to stochastic demand. A new and 2 practical second-best pricing problem with uncertain demand is proposed and formulated as a 3 stochastic mathematical program with equilibrium constraints. In view of the problem structure, 4 we develop a tailored global optimization algorithm. This algorithm incorporates a sample 5 average approxi...

This paper addresses the optimal design problem of toll ring in a general urban traffic network. This problem is categorised as a Mathematical Programming Problem with Equilibrium Constraints (MPEC) due to the implicit constraint of user equilibrium condition. In addition, the constraint on the topology of the combination of tolled links is imposed where the combination of tolled links must for...

The collection of vehicular tolls at Port Authority tunnels and bridges is one of the most important operations conducted by the police personnel. More than 250 traffic officers are utilized, and the payroll costs exceed a million dollars annually. In staffing its toll plazas the Port Authority attempts to handle traffic with a minimum number of toll collectors consistent with uniformly good se...