Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. Here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases. Materials and methods. The present cross-sect...

Study objectives: Oral lichen planus (OLP) is a well recognized chronic mucocutaneous disorder which can manifest in the oral mucosa, whose exact pathogenic mechanisms have not been understood. Estimation of serum cortisol in patients with OLP may be helpful in understanding the pathogenesis. Therefore a study was undertaken to analyze the serum cortisol levels in OLP patients. An attempt was a...

Erasmus Wilson (1869) described lichen planus for the first time.1 It is relatively common dermatological disorder occurring on skin and oral mucous membrane.2 It refers to lace like pattern produced by symbolic algae and fungal colonies on the surface of rocks in nature (Lichens). Prevalence of lichen planus in general population is about 0.9 to 1.2% and prevalence of oral lichen planus is rep...

Aerobic life is connected with continuous production of free radicals, particularly reactive oxygen species (ROS). Cells posses an enzymatic and non-enzymatic antioxidant system to maintain redox homeostasis. Oxidant-antioxidant imbalance resulting in excessive accumulation of ROS is defined as oxidative stress. Oral lichen planus (OLP) is a chronic inflammation of unknown etiology. Several res...

BACKGROUND AND AIMS Oral lichen planus (OLP) is a common chronic mucocutaneous disease. Patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. The main therapy of OLP has been the administration of topical or systemic corticosteroids. Potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus. T...

OBJECTIVES Oral lichen planus is chronic inflammatory disease with a high prevalence in the population. This study describes the epidemiological and clinical characteristics of group of patients with oral lichen planus in the Czech Republic. MATERIAL AND METHODS Data was taken from the medical records of 171 patients referred to the Oral Medicine Unit at the University Hospital in Hradec Král...

Background: Oral Lichen Planus (OLP) is a chronic autoimmune disease that could be considered as a potential premalignant status. Objective: To evaluate the miRNA-146a and miRNA-155 expression levels in patients with oral Lichen planus lesions compared to healthy subjects with normal oral mucosa. Methods: Forty patients with oral lichen planus and 18 healthy age and gender-matched controls were...

BACKGROUND The role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial. OBJECTIVES The primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls. METHODS Bibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from c...

We described and analyzed the pathogenic difference between Good syndrome (GS) and oral lichen planus (OLP) in oral mucosa. Good syndrome (GS) is a rare disease characterized by B and T cell immunodeficiency associated with hypogammaglobulinemia and thymoma. GS patients frequently develop oral lichenoid lesions with lymphocytic infiltration beneath the basal layer. Oral lichen planus (OLP) is a...