We have outlined our progress with respect to developing a novel device for monitoring oral samples for bacterial and/or viral pathogens. The system is based on an existing device for measuring drugs of abuse in an oral sample. The sample is collected on an absorbent pad that delivers a metered dose to the cassette. The sample is then separated into 4 channels for the detection of antigen, RNA ...

The deleterious and sometimes fatal outcomes of bacterial infectious diseases are the net result of the interactions between the pathogen and the host, and the genetically tractable fruit fly, Drosophila melanogaster, has emerged as a valuable tool for modeling the pathogen-host interactions of a wide variety of bacteria. These studies have revealed that there is a remarkable conservation of ba...

This chapter explores the role of Campylobacter concisus, as an emerging pathogen of the human gastrointestinal tract. This bacterium is a Gram negative curved rod that composes part of the gingival flora of the human oral cavity. The association of C. concisus with human periodontal diseases and gingivitis has been reported since the 1980s. However in this decade the focus on this species has ...

The capsular polysaccharide (CPS) of the periodontal pathogen Porphyromonas gingivalis is an important virulence factor for this organism. We purified P. gingivalis CPS, immunized mice with this antigen, and assessed the vaccine potential of P. gingivalis CPS by using the murine oral challenge model. Animals immunized with P. gingivalis CPS developed elevated levels of immunoglobulin M (IgM) an...

Background Oral microbial infections are one of the most common diseases. Their progress not only results in irreversible destruction teeth and other oral tissues but also closely links to cancers systemic However, traditional treatment against by antibiotics is effective enough due resistance drug blocking biofilms, along with passive dilution on infection site environment. Aim review Besides ...