The plasma membranes of most if not all vertebrate cells contain a transport system that mediates the transmembrane exchange of sodium for hydrogen. The kinetic properties of this transport system include a 1:1 stoichiometry, affinity for lithium and ammonium ion in addition to sodium and hydrogen, the ability to function in multiple 1:1 exchange modes involving these four cations, sensitivity ...

Iwamoto, Takahiro. Vascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290: R536–R545, 2006; doi:10.1152/ajpregu.00592.2005.—The Na /Ca exchanger is an ion transporter that exchanges Na and Ca in either Ca efflux or Ca influx mode, depending on membrane potential and transmembrane ion gradients. In arter...

The task of purifying monoclonal antibodies (MAbs) and human recombinant antithrombin III (rATIII) from cell culture supernatant was carried out using two different approaches, both based on the use of membraneous matrices. The first approach employed a strongly acidic and a strongly basic membrane ion exchanger, which were evaluated for their ability to purify monoclonal antibodies and the hum...

Iwamoto, Takahiro. Vascular Na /Ca exchanger: implications for the pathogenesis and therapy of salt-dependent hypertension. Am J Physiol Regul Integr Comp Physiol 290: R536–R545, 2006; doi:10.1152/ajpregu.00592.2005.—The Na /Ca exchanger is an ion transporter that exchanges Na and Ca in either Ca efflux or Ca influx mode, depending on membrane potential and transmembrane ion gradients. In arter...

Direct drug determination without any pervious treatment steps is the most environmentally friendly method of analysis. Traditional analysis methods usually involve a pre-treatment step before analysis and this consumes time and organic solvents. This work describes direct potentiometric method by using ion selective electrode to determine Montelukast Sodium in its pure drug substance and in ta...

Yeast Nhx1 [Na+(K+)/H+ exchanger 1] is an intracellular Na+(K+)/H+ exchanger, localizing to the late endosome where it is important for ion homoeostasis and vesicle trafficking. Phylogenetic analysis of NHE (Na+/H+ exchanger) sequences has identified orthologous proteins, including HsNHE6 (human NHE6), HsNHE7 and HsNHE9 of unknown physiological role. These appear distinct from well-studied mamm...

The membrane-bound sodium-calcium exchanger (NCX) proteins shape Ca2+ homeostasis in many cell types, thus participating in a wide range of physiological and pathological processes. Determination of the crystal structure of an archaeal NCX (NCX_Mj) paved the way for a thorough and systematic investigation of ion transport mechanisms in NCX proteins. Here, we review the data gathered from the X-...