OBJECTIVES To measure the impact of occupational and lifestyle factors on concentrations of organochlorine compounds in a general population sample living near an electrochemical factory with a high airborne concentration of hexachlorobenzene (HCB). METHODS Serum samples from 608 people (328 selected from a random sample) were collected in 1994. Information on lifestyles, occupation, and medi...

Although benign, uterine leiomyomas occur with high frequency and significant morbidity in reproductive-age women, and they present a significant health problem. Leiomyomas develop in the uterine myometrium and are sensitive to ovarian hormones, making them potential target sites for endocrine disruptors. Here we utilize cell lines derived from rat uterine leiomyomas to determine if a panel of ...

BACKGROUND Chlorinated pesticides have been used in pest control for several decades in the world. These compounds are still applied in many regions, and their continuous usage has resulted in their bioaccumulation and residue in the food chain. These residues could transfer to food products and accumulate in fat tissues. Undoubtedly, the breast milk could be a significant biomarker for estimat...

Levels of organochlorine compounds (chlorobiphenyls and organochlorine pesticides) were measured in the blubber of 12 marine mammal species collected from strandings around the Scottish and Irish coast. Included are the first contaminant data to be reported in the blubber of the Sowerbys beaked whale (Mesoploden bidens). Twenty CBs were measured, including the toxic non-ortho substituted congen...

Organic contaminants [polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), polybrominated diphenylethers (PBDEs), nonylphenols], organotin compounds and trace metals (cadmium, chromium, mercury and zinc) were determined in flounder (Platichthys flesus) liver and sediment from the Amsterdam harbour (North Sea Canal) and Rotterdam harbour (Euromonding) and off the Dutch coast betwe...

I would like to respond to the comments of Jongbloet et al. (1) on the data of Mocarelli et al. (2). Mocarelli et al. (2) reported on the offspring sex ratios (proportions male) following the explosion at Seveso, Italy, that released 2,3,7,8-tetrachlorodibenzo-pdioxin (TCDD, dioxin) into the environment. Mocarelli et al. (2) categorized matings into the four possible combinations by sex and exp...

In this study we evaluated residential location as a potential determinant for exposure to organochlorine compounds. We investigated the geographic distribution characteristics of organochlorine levels in approximately 1,374 blood samples collected in 1974 from residents of a community with a potential organochlorine source. Street addresses of Washington County, Maryland, residents were obtain...